An approach towards bronchoscopic-based gene therapy using electrical field accelerated plasmid droplets
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2012
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04B - Conference paper
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2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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IEEE
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New York
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Abstract
Idiopathic pulmonary fibrosis (IPF) is a
devastating disease affecting the distal lung, due to failure of
the alveolar epithelium to heal after micro-injuries, leading to
inefficient gas exchange and resulting in death. Therapeutic
options are very limited. A new therapeutic approach based on
gene therapy restores the self-healing process within the lung in
the experimental setup.
A basic requirement of this therapy is the successful
transduction of genes into the alveolar epithelium in the distal
part of the lung, for which a new therapeutic instrument is
required. In this paper we present the concept and first
experimental results of a device which uses an electrical field to
accelerate the charged droplets of plasmid suspension toward
the tissue and which overcomes cell membrane with its impact
energy. The aim is to develop a therapeutic device capable of
being integrated into minimally invasive procedures such as
bronchoscopy.
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Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Event
34th Annual International Conference of the IEEE EMBS
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28.08.2012
Conference end date
01.09.2012
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English
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Yes
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Published
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Closed
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HRADETZKY, David, Stephan BOEHRINGER, Thomas GEISER und Amiq GAZDHAR, 2012. An approach towards bronchoscopic-based gene therapy using electrical field accelerated plasmid droplets. In: 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. New York: IEEE. 2012. Verfügbar unter: https://irf.fhnw.ch/handle/11654/46668