Current challenges and future perspectives in oral absorption research. An opinion of the UNGAP network

dc.accessRightsAnonymous*
dc.contributor.authorKuentz, Martin
dc.contributor.authorVinarov, Zahari
dc.contributor.authorBertil, Abrahamsson
dc.contributor.authorArtursson, Per
dc.contributor.authorBatchelor, Hannah
dc.contributor.authorBerben, Philippe
dc.contributor.authorBernkop-Schnürch, Andreas
dc.contributor.authorButler, James
dc.contributor.authorCeulemans, Jens
dc.contributor.authorDavies, Nigel
dc.contributor.authorDupont, Didier
dc.contributor.authorEide Flaten, Goril
dc.contributor.authorFotaki, Nikoleta
dc.contributor.authorJannin, Vincent
dc.contributor.authorKeemink, Janneke
dc.contributor.authorKesisoglou, Filippos
dc.contributor.authorKoziolek, Mirko
dc.contributor.authorAugustijns, Patrick
dc.contributor.authorGriffin, Brendan
dc.date.accessioned2022-02-18T10:22:43Z
dc.date.available2022-02-18T10:22:43Z
dc.date.issued2021-04
dc.description.abstractAlthough oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.en_US
dc.identifier.doi10.1016/j.addr.2021.02.001
dc.identifier.issn1872-8294
dc.identifier.issn0169-409X
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/33311
dc.identifier.urihttps://doi.org/10.26041/fhnw-4104
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofAdvanced Drug Delivery Reviewsen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/en_US
dc.subjectSpecific patient populationsen_US
dc.subjectRegional differencesen_US
dc.subjectAdvanced formulationsen_US
dc.subjectAmorphous solid dispersionsen_US
dc.subjectLipid-based formulationsen_US
dc.subjectFood-drug interactionsen_US
dc.subjectMicrobiomeen_US
dc.subjectIn vitro toolsen_US
dc.subjectPBPK modelingen_US
dc.titleCurrent challenges and future perspectives in oral absorption research. An opinion of the UNGAP networken_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume171en_US
dspace.entity.typePublication
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.openAccessCategoryHybriden_US
fhnw.pagination289-331en_US
fhnw.publicationStatePublisheden_US
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
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