Modeling-Based Approach Towards Quality by Design for a Telescoped Process
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Authors
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Publication date
2022
Typ of student thesis
Bachelor
Course of study
Collections
Type
11 - Student thesis
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Hochschule für Life Sciences FHNW
Place of publication / Event location
Muttenz
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Abstract
A synthesis step, consisting of two sub-steps A and B was investigated by applying a model based approach. Deepening the process understanding was achieved through performed experiments, which also led to the generation of valuable knowledge for future improvements. A kinetic model consisting of 12 reactions and 15 components was successfully established. The model predicts the effects of changes in process parameters on quality. On this basis recommendations for process optimizations have been formulated.
Keywords
Scale-Up / Scale-Down, Quality By Design (QBD), Process Modelling, Process Simulation, Reaction Kinetics
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Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
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Review
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Citation
ZOGG, Andreas und This ZAHND, 2022. Modeling-Based Approach Towards Quality by Design for a Telescoped Process. Muttenz: Hochschule für Life Sciences FHNW. Verfügbar unter: https://doi.org/10.26041/fhnw-4710