Fabrication and characterization of PCL/HA filament as a 3D printing material using thermal extrusion technology for bone tissue engineering
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Authors
Wang, Fengze
Tankus, Esma Bahar
Santarella, Francesco
Rohr, Nadja
Sharma, Neha
Märtin, Sabrina
Michalscheck, Mirja
Cao, Shuaishuai
Thieringer, Florian M.
Author (Corporation)
Publication date
11.02.2022
Typ of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Polymers
Special issue
DOI of the original publication
Link
Series
Series number
Volume
14
Issue / Number
4
Pages / Duration
1-14
Patent number
Publisher / Publishing institution
MDPI
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
The most common three-dimensional (3D) printing method is material extrusion, where a pre-made filament is deposited layer-by-layer. In recent years, low-cost polycaprolactone (PCL) material has increasingly been used in 3D printing, exhibiting a sufficiently high quality for consideration in cranio-maxillofacial reconstructions. To increase osteoconductivity, prefabricated filaments for bone repair based on PCL can be supplemented with hydroxyapatite (HA). However, few reports on PCL/HA composite filaments for material extrusion applications have been documented. In this study, solvent-free fabrication for PCL/HA composite filaments (HA 0%, 5%, 10%, 15%, 20%, and 25% weight/weight PCL) was addressed, and parameters for scaffold fabrication in a desktop 3D printer were confirmed. Filaments and scaffold fabrication temperatures rose with increased HA content. The pore size and porosity of the six groups’ scaffolds were similar to each other, and all had highly interconnected structures. Six groups’ scaffolds were evaluated by measuring the compressive strength, elastic modulus, water contact angle, and morphology. A higher amount of HA increased surface roughness and hydrophilicity compared to PCL scaffolds. The increase in HA content improved the compressive strength and elastic modulus. The obtained data provide the basis for the biological evaluation and future clinical applications of PCL/HA material.
Keywords
Polycaprolactone (PCL), Hydroxyapatite (HA), Material extrusion, Three-dimensional printing, Hydrophilicity, Mechanical testing
Subject (DDC)
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ISBN
ISSN
1879-1344
0144-8617
0144-8617
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
License
Citation
Wang, F., Tankus, E. B., Santarella, F., Rohr, N., Sharma, N., Märtin, S., Michalscheck, M., Cao, S., Maintz, M., & Thieringer, F. M. (2022). Fabrication and characterization of PCL/HA filament as a 3D printing material using thermal extrusion technology for bone tissue engineering. Polymers, 14(4), 1–14. https://doi.org/10.3390/polym14040669