Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

dc.accessRightsAnonymous
dc.audienceScience
dc.contributor.authorLipps, Georg
dc.date.accessioned2016-10-21T10:29:40Z
dc.date.available2016-10-21T10:29:40Z
dc.date.issued2016-04-26
dc.description.abstractRecent research has demonstrated that all body fluids assessed contain substantial amts. of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes contg. different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-​called extracellular vesicles (EVs) are nanosized exosomes (70-​150 nm)​, which are derivs. of the endosomal system, and microvesicles (100-​1000 nm)​, which are produced by outward budding of the plasma membrane. Nanosized EVs are released by almost all cell types and mediate targeted intercellular communication under physiol. and pathophysiol. conditions. Contg. cell-​type-​specific signatures, EVs have been proposed as biomarkers in a variety of diseases. Furthermore, according to their phys. functions, EVs of selected cell types have been used as therapeutic agents in immune therapy, vaccination trials, regenerative medicine, and drug delivery. Undoubtedly, the rapidly emerging field of basic and applied EV research will significantly influence the biomedicinal landscape in the future. In this Perspective, we, a network of European scientists from clin., academic, and industry settings collaborating through the H2020 European Cooperation in Science and Technol. (COST) program European Network on Microvesicles and Exosomes in Health and Disease (ME-​HAD)​, demonstrate the high potential of nanosized EVs for both diagnostic and therapeutic (i.e., theranostic) areas of nanomedicine.
dc.identifier.doi10.1021/acsnano.5b08015
dc.identifier.issn1936-0851
dc.identifier.issn1936-086X
dc.identifier.urihttp://hdl.handle.net/11654/23404
dc.issue4
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Nanoen_US
dc.subjectextracellular vesicles
dc.subjectnanomedicine
dc.titleEvidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume10
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandNo
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Chemie und Bioanalytikde_CH
fhnw.pagination3886-3899
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
relation.isAuthorOfPublication30d5ac4a-5f57-468d-95b9-695fcc98d1bd
relation.isAuthorOfPublication.latestForDiscovery30d5ac4a-5f57-468d-95b9-695fcc98d1bd
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