Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological systems (MPSs), closely replicate tissue environments and human physiology, enhancing research and biomedical uses. However, MPS complexity introduces standardization challenges, impacting reproducibility and trust. We offer guidelines for quality management and control criteria specific to MPSs, facilitating reliable outcomes without stifling innovation. Our fit-for-purpose recommendations provide actionable advice for achieving consistent MPS performance.

Schlagwörter

Fachgebiet (DDC)

500 - Naturwissenschaften und Mathematik

Projekt

Veranstaltung

Startdatum der Ausstellung

Enddatum der Ausstellung

Startdatum der Konferenz

Enddatum der Konferenz

Datum der letzten Prüfung

ISBN

ISSN

2213-6711

Sprache

Englisch

Während FHNW Zugehörigkeit erstellt

Ja

Zukunftsfelder FHNW

Publikationsstatus

Veröffentlicht

Begutachtung

Peer-Review der ganzen Publikation

Open Access-Status

Gold

Lizenz

Zitation

PAMIES, David, Jason EKERT, Marie-Gabrielle ZURICH, Olivier FREY, Sophie WERNER, Monica PIERGIOVANNI, Benjamin S. FREEDMAN, Adrian Kee KEONG TEO, Hendrik ERFURTH, Darwin R. REYES, Peter LOSKILL, Pelin CANDARLIOGLU, Laura SUTER-DICK, Shan WANG, Thomas HARTUNG, Sandra COECKE, Glyn N. STACEY, Beren Atac WAGEGG, Eva-Maria DEHNE, Francesca PISTOLLATO und Marcel LEIST, 2024. Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility. Stem Cell Reports. Mai 2024. Bd. 19, Nr. 5, S. 604–617. DOI 10.1016/j.stemcr.2024.03.009. Verfügbar unter: https://doi.org/10.26041/fhnw-11822

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