Improvements in PM10 Exposure and Reduced Rates of Respiratory Symptoms in a Cohort of Swiss Adults (SAPALDIA)
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Publication date
2009
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01A - Journal article
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American Journal of Respiratory and Critical Care Medicine
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Volume
179
Issue / Number
7
Pages / Duration
579-587
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Publisher / Publishing institution
American Thoracic Society
Place of publication / Event location
New York
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Abstract
Rationale: Reductions in mortality following improvements in air quality were documented by several studies, and our group found, in an earlier analysis, that decreasing particulate levels attenuate lung function decline in adults.
Objectives: We investigated whether decreases in particulates with an aerodynamic diameter of less than 10 microm (PM10) were associated with lower rates of reporting respiratory symptoms (i.e., decreased morbidity) on follow-up.
Methods: The present analysis includes 7,019 subjects who underwent detailed baseline examinations in 1991 and a follow-up interview in 2002. Each subject was assigned model-based estimates of average PM10 during the 12 months preceding each health assessment and the difference was used as the exposure variable of interest (DeltaPM10). Analyses were stratified by symptom status at baseline and associations between DeltaPM10 and change in symptom status during follow-up were adjusted for important baseline characteristics, smoking status at follow-up, and season. We then estimated adjusted odds ratios for symptoms at follow-up and numbers of symptomatic cases prevented due to the observed reductions in PM10.
Measurements and main results: Residential exposure to PM10 was lower in 2002 than in 1991 (mean decline 6.2 microg/m3; SD = 3.9 microg/m3). Estimated benefits (per 10,000 persons) attributable to the observed changes in PM10-levels were: 259 (95% confidence interval [CI]: 102-416) fewer subjects with regular cough, 179 (95% CI, 30-328) fewer subjects with chronic cough or phlegm and 137 (95% CI, 9-266) fewer subjects with wheezing and breathlessness.
Conclusions: Reductions in particle levels in Switzerland over the 11-year follow-up period had a beneficial effect on respiratory symptoms among adults.
Keywords
Subject (DDC)
300 - Sozialwissenschaften, Soziologie, Anthropologie
610 - Medizin und Gesundheit
610 - Medizin und Gesundheit
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1073-449X
1535-4970
1535-4970
Language
English
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No
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Publication status
Published
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Peer review of the complete publication
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Closed
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Citation
SCHINDLER, Christian, Dirk KEIDEL, Margaret W. GERBASE, Elisabeth ZEMP, Robert BETTSCHART, Otto BRÄNDLI, Martin H. BRUTSCHE, Luc BURDET, Werner KARRER, Bruno KNÖPFLI, Marco PONS, Regula RAPP, Lucy BAYER-OGLESBY, Nino KÜNZLI, Joel SCHWARTZ, Lee-Jane S. LIU, Ursula ACKERMANN-LIEBRICH und Thierry ROCHAT, 2009. Improvements in PM10 Exposure and Reduced Rates of Respiratory Symptoms in a Cohort of Swiss Adults (SAPALDIA). American Journal of Respiratory and Critical Care Medicine. 2009. Bd. 179, Nr. 7, S. 579–587. DOI 10.1164/rccm.200803-388OC. Verfügbar unter: https://irf.fhnw.ch/handle/11654/45626