Sequencing of the M protein. Toward personalized medicine in monoclonal gammopathies
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Authors
Cascino, Pasquale
Nevone, Alice
Piscitelli, Maggie
Scopelliti, Claudia
Girelli, Maria
Mazzini, Giulia
Caminito, Serena
Russo, Giancarlo
Milani, Paolo
Basset, Marco
Author (Corporation)
Publication date
23.08.2022
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01A - Journal article
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Parent work
American Journal of Hematology
Special issue
DOI of the original publication
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Series
Series number
Volume
97
Issue / Number
11
Pages / Duration
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Publisher / Publishing institution
Wiley
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Abstract
Each patient with a monoclonal gammopathy has a unique monoclonal (M) protein, whose sequence can be used as a tumoral fingerprint to track the presence of the B cell or plasma cell (PC) clone itself. Moreover, the M protein can directly cause potentially life-threatening organ damage, which is dictated by the specific, patient's unique clonal light and/or heavy chain amino acid sequence, as in patients affected by immunoglobulin light chain (AL) amyloidosis.1 However, patients' specific M protein sequences remain mostly undefined and molecular mechanisms underlying M protein-related clinical manifestations are largely obscure.
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Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
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ISSN
0361-8609
1096-8652
1096-8652
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
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Citation
CASCINO, Pasquale, Alice NEVONE, Maggie PISCITELLI, Claudia SCOPELLITI, Maria GIRELLI, Giulia MAZZINI, Serena CAMINITO, Giancarlo RUSSO, Paolo MILANI, Marco BASSET, Andrea FOLI, Francesca FAZIO, Simona CASARINI, Margherita MASSA, Margherita BOZZOLA, Jessica RIPEPI, Melania Antonietta SESTA, Gloria ACQUAFREDDA, Marica DE CICCO, Antonia MORETTA, Paola ROGNONI, Enrico MILAN, Stefano RICAGNO, Francesca LAVATELLI, Maria Teresa PETRUCCI, Catherine KLERSY, Giampaolo MERLINI, Giovanni PALLADINI, Mario NUVOLONE und Enkelejda MIHO, 2022. Sequencing of the M protein. Toward personalized medicine in monoclonal gammopathies. American Journal of Hematology. 23 August 2022. Bd. 97, Nr. 11. DOI 10.1002/ajh.26684. Verfügbar unter: https://irf.fhnw.ch/handle/11654/34550