Sequencing of the M protein. Toward personalized medicine in monoclonal gammopathies
Type
01A - Beitrag in wissenschaftlicher Zeitschrift
Zusammenfassung
Each patient with a monoclonal gammopathy has a unique monoclonal (M) protein, whose sequence can be used as a tumoral fingerprint to track the presence of the B cell or plasma cell (PC) clone itself. Moreover, the M protein can directly cause potentially life-threatening organ damage, which is dictated by the specific, patient's unique clonal light and/or heavy chain amino acid sequence, as in patients affected by immunoglobulin light chain (AL) amyloidosis.1 However, patients' specific M protein sequences remain mostly undefined and molecular mechanisms underlying M protein-related clinical manifestations are largely obscure.
DOI der Originalausgabe
https://doi.org/10.1002/ajh.26684Übergeordnetes Werk
American Journal of Hematology
Jahrgang
97
Ausgabe
11
Verlag / Hrsg. Institution
Wiley