Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds
Author (Corporation)
Publication date
2023
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Journal of Chemistry and Technologies
Special issue
DOI of the original publication
Link
Series
Series number
Volume
31
Issue / Number
2
Pages / Duration
255-270
Patent number
Publisher / Publishing institution
Oles Honchar Dnipro National University
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
Digestive enzymes and inhibitors of digestive enzymes are effective correctors of digestive processes in the body, the violation of which leads to various diseases (diabetes, hyperlipidemia, cardiovascular diseases, neoplasms and others). The present study identified the most promising plant objects characterized by the highest antilipolytic activity (ALA) in relation to pancreatic lipase. The experimental results indicate that the inhibitory activity (IA) of phenolic compounds of rapeseed is so much high and comparable to ALA "Orlistat", reaching 95.5 % of its activity. This determines the potential possibility of using the phenolic complex of rapeseed as an alternative to anti-lipolytic drugs of synthetic origin. The predominant component of the phenolic complex is low molecular weight phenolic compounds; polyphenolic compounds are almost equally represented by tannins – condensed and hydrolyzable. According to TLC data, the main components of low molecular weight phenols are glucopyranosylsinapate, sinapic acid and sinapin. Among the phenolic compounds of rapeseed seeds, sinapine and hydrolyzable tannins have the highest anti lipolytic activity against lipase. Significant ability to inhibit the action of pancreatic lipase is characterized by both low molecular weight and high molecular weight phenolic compounds of rapeseed.
Keywords
Subject (DDC)
500 - Naturwissenschaften und Mathematik
Event
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Exhibition end date
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ISBN
ISSN
2663-2934
2663-2942
2663-2942
Language
Other
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
Citation
KRUSIR, Galyna, Liudmyla PYLYPENKO, Elena SEVASTYANOVA, Kseniia MAZURENKO, Serhii MOSHTAKOV, Hanna SHUNKO, Antonina VITIUK, Tetyana SHPYRKO und Oleksandr ZDORYK, 2023. Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds. Journal of Chemistry and Technologies. 2023. Bd. 31, Nr. 2, S. 255–270. DOI 10.15421/jchemtech.v31i2.279214. Verfügbar unter: https://doi.org/10.26041/fhnw-7957