Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds

Digestive enzymes and inhibitors of digestive enzymes are effective correctors of digestive processes in the body, the violation of which leads to various diseases (diabetes, hyperlipidemia, cardiovascular diseases, neoplasms and others). The present study identified the most promising plant objects characterized by the highest antilipolytic activity (ALA) in relation to pancreatic lipase. The experimental results indicate that the inhibitory activity (IA) of phenolic compounds of rapeseed is so much high and comparable to ALA "Orlistat", reaching 95.5 % of its activity. This determines the potential possibility of using the phenolic complex of rapeseed as an alternative to anti-lipolytic drugs of synthetic origin. The predominant component of the phenolic complex is low molecular weight phenolic compounds; polyphenolic compounds are almost equally represented by tannins – condensed and hydrolyzable. According to TLC data, the main components of low molecular weight phenols are glucopyranosylsinapate, sinapic acid and sinapin. Among the phenolic compounds of rapeseed seeds, sinapine and hydrolyzable tannins have the highest anti lipolytic activity against lipase. Significant ability to inhibit the action of pancreatic lipase is characterized by both low molecular weight and high molecular weight phenolic compounds of rapeseed.

Schlagwörter

Fachgebiet (DDC)

500 - Naturwissenschaften und Mathematik

Projekt

Veranstaltung

Startdatum der Ausstellung

Enddatum der Ausstellung

Startdatum der Konferenz

Enddatum der Konferenz

Datum der letzten Prüfung

ISBN

ISSN

2663-2934
2663-2942

Sprache

Andere

Während FHNW Zugehörigkeit erstellt

Ja

Zukunftsfelder FHNW

Publikationsstatus

Veröffentlicht

Begutachtung

Peer-Review der ganzen Publikation

Open Access-Status

Gold

Lizenz

Zitation

Krusir, G., Pylypenko, L., Sevastyanova, E., Mazurenko, K., Moshtakov, S., Shunko, H., Vitiuk, A., Shpyrko, T., & Zdoryk, O. (2023). Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds. Journal of Chemistry and Technologies, 31(2), 255–270. https://doi.org/10.15421/jchemtech.v31i2.279214

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