Characterization of a cotton-wool like composite bone graft material

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dc.accessRightsAnonymous*
dc.contributor.authorRohr, Nadja
dc.contributor.authorBrunner, Claudia
dc.contributor.authorBellon, Benjamin
dc.contributor.authorFischer, Jens
dc.contributor.authorde Wild, Michael
dc.date.accessioned2022-10-12T09:45:12Z
dc.date.available2022-10-12T09:45:12Z
dc.date.issued2022-07-18
dc.description.abstractBone graft materials are applied in patients to augment bone defects and enable the insertion of an implant in its ideal position. However, the currently available augmentation materials do not meet the requirements of being completely resorbed and replaced by new bone within 3 to 6 months. A novel electrospun cotton-wool like material (Bonewool, Zurich Biomaterials LLC, Zurich, Switzerland) consisting of biodegradable poly(lactic-co-glycolic) acid (PLGA) fibers with incorporated amorphous ß-tricalcium phosphate (ß-TCP) nanoparticles has been compared to a frequently used bovine derived hydroxyapatite (Bio-Oss, Geistlich Pharma, Wolhusen, Switzerland) in vitro. The material composition was determined and the degradation behavior (calcium release and pH in different solutions) as well as bioactivity has been measured. Degradation behavior of PLGA/ß-TCP was generally more progressive than for Bio-Oss, indicating that this material is potentially completely resorbable.en_US
dc.identifier.doi10.1007/s10856-022-06682-3
dc.identifier.issn1573-4838
dc.identifier.issn0957-4530
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/33935
dc.identifier.urihttps://doi.org/10.26041/fhnw-4322
dc.issue8en_US
dc.language.isodeen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectBonewoolen_US
dc.subjectbone augmentationen_US
dc.subjectBio-Ossen_US
dc.subjecthydroxyapatiteen_US
dc.subjecttricalcium phosphateen_US
dc.subjectPLGAen_US
dc.subject.ddc500 - Naturwissenschaftenen_US
dc.titleCharacterization of a cotton-wool like composite bone graft materialen_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume33en_US
dspace.entity.typePublication
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Medizintechnik und Medizininformatikde_CH
fhnw.openAccessCategoryGolden_US
fhnw.publicationStatePublisheden_US
relation.isAuthorOfPublication135938a9-969d-4ea3-9bb2-7ff1d77554cb
relation.isAuthorOfPublication.latestForDiscovery135938a9-969d-4ea3-9bb2-7ff1d77554cb
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