Soft nanocarriers as antimicrobial co‐delivery systems to combat resistant infections
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Author (Corporation)
Publication date
08.2025
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
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Parent work
Advanced Healthcare Materials
Special issue
DOI of the original publication
Link
Series
Series number
Volume
14
Issue / Number
21
Pages / Duration
2404540
Patent number
Publisher / Publishing institution
Wiley
Place of publication / Event location
Edition
Version
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Abstract
The rise of antimicrobial resistance (AMR) poses a global health challenge, driving the need for innovative solutions to effective treatment and prevention. The advancing field of nanotechnology has facilitated the development of nanocarriers based on polymer and lipid excipients with precisely controlled compositions, release mechanisms, and targeted biological interactions. These “soft” nanocarriers can be tailored to deliver multiple antimicrobial drugs with complementary mechanisms of action, offering an effective strategy to prevent and combat AMR. This review highlights the design and applications of nanocarriers as co-delivery systems, emphasizing their potential for optimized drug loading, spatio-temporal control of release, and pathogen-specific targeting. The unique benefits of diverse nanocarrier types, including lipid-based, polymer-based, and hybrid systems, are covered with a comprehensive set of examples from recent literature in multidrug encapsulation and synergistic antimicrobial therapies. The review also delves into the key challenges in achieving precise control over the sequence and rate of release, ensuring pathogen specificity, and overcoming biological barriers such as biofilms, and provides perspectives on future research efforts to advance nanocarrier engineering and optimization strategies to develop robust, targeted treatments capable of addressing the urgent threat of resistant infections.
Keywords
Antimicrobial resistance, Antimicrobials, Co-delivery, Hybrids, Lipids, Nanocarriers, Polymers
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ISBN
ISSN
2192-2640
2192-2659
2192-2659
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
License
Citation
Nikoletic, A., Natsaridis, E., Flathmann, T., Cunha De Quadros, D. P., Gogniat, N., & Tagit, O. (2025). Soft nanocarriers as antimicrobial co‐delivery systems to combat resistant infections. Advanced Healthcare Materials, 14(21), 2404540. https://doi.org/10.1002/adhm.202404540