Soft nanocarriers as antimicrobial co‐delivery systems to combat resistant infections
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Autor:in (Körperschaft)
Publikationsdatum
08.2025
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Advanced Healthcare Materials
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
14
Ausgabe / Nummer
21
Seiten / Dauer
2404540
Patentnummer
Verlag / Herausgebende Institution
Wiley
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The rise of antimicrobial resistance (AMR) poses a global health challenge, driving the need for innovative solutions to effective treatment and prevention. The advancing field of nanotechnology has facilitated the development of nanocarriers based on polymer and lipid excipients with precisely controlled compositions, release mechanisms, and targeted biological interactions. These “soft” nanocarriers can be tailored to deliver multiple antimicrobial drugs with complementary mechanisms of action, offering an effective strategy to prevent and combat AMR. This review highlights the design and applications of nanocarriers as co-delivery systems, emphasizing their potential for optimized drug loading, spatio-temporal control of release, and pathogen-specific targeting. The unique benefits of diverse nanocarrier types, including lipid-based, polymer-based, and hybrid systems, are covered with a comprehensive set of examples from recent literature in multidrug encapsulation and synergistic antimicrobial therapies. The review also delves into the key challenges in achieving precise control over the sequence and rate of release, ensuring pathogen specificity, and overcoming biological barriers such as biofilms, and provides perspectives on future research efforts to advance nanocarrier engineering and optimization strategies to develop robust, targeted treatments capable of addressing the urgent threat of resistant infections.
Schlagwörter
Antimicrobial resistance, Antimicrobials, Co-delivery, Hybrids, Lipids, Nanocarriers, Polymers
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
2192-2640
2192-2659
2192-2659
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Hybrid
Lizenz
Zitation
Nikoletic, A., Natsaridis, E., Flathmann, T., Cunha De Quadros, D. P., Gogniat, N., & Tagit, O. (2025). Soft nanocarriers as antimicrobial co‐delivery systems to combat resistant infections. Advanced Healthcare Materials, 14(21), 2404540. https://doi.org/10.1002/adhm.202404540