Physiological dependency explains temperature differences in sensitivity towards chemical exposure
Loading...
Authors
Rakel, Kim
Becker, Denis
Bussen, Dino
Classen, Silke
Preuss, Thomas
Strauss, Tido
Gergs, André
Author (Corporation)
Publication date
20.10.2022
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Archives of Environmental Contamination and Toxicology
Special issue
DOI of the original publication
Link
Series
Series number
Volume
83
Issue / Number
4
Pages / Duration
349-360
Patent number
Publisher / Publishing institution
Springer
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
In chemical risk assessment, extrapolations from laboratory tests to more realistic conditions are essential to address the toxic effects of pesticides on individuals and populations under field conditions. To transfer toxicological laboratory tests to differing temperature conditions, or outdoor field scenarios, the consideration of temperature dependence is essential and increases realism. Special consideration is given to the impact of temperature on direct sensitivity of organisms to pesticides, for which there are only few modelling approaches available so far. We present a concept for applying physiological temperature dependencies to toxicokinetic–toxicodynamic (TKTD) parameters in the General Uniformed Threshold model of Survival (GUTS). To test this approach in an exemplary study, temperature dependencies from studies on the developmental rate of the mayfly Cloeon dipterum were applied to the parameters of a previously parameterised TKTD model of this species after exposure to imidacloprid. Using a physiologically derived temperature correction for the TKTD rate constants, model predictions for independently conducted toxicology experiments with temperature ranges between 7.8 and 26.4 °C were performed for validation. Our approach demonstrates the successful transfer of a physiological observed temperature dependency on toxicity parameters and survival patterns for Cloeon dipterum and imidacloprid as a case study.
Keywords
Subject (DDC)
Event
Exhibition start date
Exhibition end date
Conference start date
Conference end date
Date of the last check
ISBN
ISSN
0090-4341
1432-0703
1432-0703
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
License
Citation
Rakel, K., Becker, D., Bussen, D., Classen, S., Preuss, T., Strauss, T., Zenker, A., & Gergs, A. (2022). Physiological dependency explains temperature differences in sensitivity towards chemical exposure. Archives of Environmental Contamination and Toxicology, 83(4), 349–360. https://doi.org/10.1007/s00244-022-00963-2