A Biocatalytic Nanomaterial for the Label-Free Detection of Virus-Like Particles

dc.accessRightsAnonymous
dc.audiencePraxis
dc.contributor.authorSykora, Sabine
dc.contributor.authorCorrero, Maria Rita
dc.contributor.authorMoridi, Negar
dc.contributor.authorBelliot, Gaël
dc.contributor.authorPothier, Pierre
dc.contributor.authorDudal, Yves
dc.contributor.authorCorvini, Philippe
dc.contributor.authorShahgaldian, Patrick
dc.date.accessioned2018-01-23T08:28:17Z
dc.date.available2018-01-23T08:28:17Z
dc.date.issued2017
dc.description.abstractThe design of nanomaterials that are capable of specific and sensitive biomolecular recognition is an on-going challenge in the chemical and biochemical sciences. A number of sophisticated artificial systems have been designed to specifically recognize a variety of targets. However, methods based on natural biomolecular detection systems using antibodies are often superior. Besides greater affinity and selectivity, antibodies can be easily coupled to enzymatic systems that act as signal amplifiers, thus permitting impressively low detection limits. The possibility to translate this concept to artificial recognition systems remains limited due to design incompatibilities. Here we describe the synthesis of a synthetic nanomaterial capable of specific biomolecular detection by using an internal biocatalytic colorimetric detection and amplification system. The design of this nanomaterial relies on the ability to accurately grow hybrid protein-organosilica layers at the surface of silica nanoparticles. The method allows for label-free detection and quantification of targets at picomolar concentrations.
dc.identifier.doi10.1002/cbic.201700126
dc.identifier.issn1439-7633
dc.identifier.issn1439-4227
dc.identifier.urihttp://hdl.handle.net/11654/25888
dc.issue11
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofChemBioChemen_US
dc.subjectBiocatalytic
dc.subjectnanomaterials
dc.subjectlabel-free detection
dc.subjectVirus-like Particles
dc.titleA Biocatalytic Nanomaterial for the Label-Free Detection of Virus-Like Particles
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume18
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandNo
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Chemie und Bioanalytikde_CH
fhnw.pagination996-1000
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
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Dateien