Differences in autophagy marker levels at birth in preterm vs. term infants
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Author (Corporation)
Publication date
29.05.2024
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01A - Journal article
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Parent work
Pediatric Research
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DOI of the original publication
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Volume
96
Issue / Number
5
Pages / Duration
1299–1305
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Nature
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Abstract
Background
Preterm infants are susceptible to oxidative stress and prone to respiratory diseases. Autophagy is an important defense mechanism against oxidative-stress-induced cell damage and involved in lung development and respiratory morbidity. We hypothesized that autophagy marker levels differ between preterm and term infants.
Methods
In the prospective Basel-Bern Infant Lung Development (BILD) birth cohort we compared cord blood levels of macroautophagy (Beclin-1, LC3B), selective autophagy (p62) and regulation of autophagy (SIRT1) in 64 preterm and 453 term infants.
Results
Beclin-1 and LC3B did not differ between preterm and term infants. However, p62 was higher (0.37, 95% confidence interval (CI) 0.05;0.69 in log2-transformed level, p = 0.025, padj = 0.050) and SIRT1 lower in preterm infants (−0.55, 95% CI −0.78;−0.31 in log2-transformed level, padj < 0.001). Furthermore, p62 decreased (padj-value for smoothing function was 0.018) and SIRT1 increased (0.10, 95% CI 0.07;0.13 in log2-transformed level, padj < 0.001) with increasing gestational age.
Conclusion
Our findings suggest differential levels of key autophagy markers between preterm and term infants. This adds to the knowledge of the sparsely studied field of autophagy mechanisms in preterm infants and might be linked to impaired oxidative stress response, preterm birth, impaired lung development and higher susceptibility to respiratory morbidity in preterm infants.
Impact
To the best of our knowledge, this is the first study to investigate autophagy marker levels between human preterm and term infants in a large population-based sample in cord blood plasma. This study demonstrates differential levels of key autophagy markers in preterm compared to term infants and an association with gestational age. This may be linked to impaired oxidative stress response or developmental aspects and provide bases for future studies investigating the association with respiratory morbidity
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ISBN
ISSN
0031-3998
1530-0447
1530-0447
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
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Citation
Künstle, N., Gorlanova, O., Marten, A., Müller, L., Sharma, P., Röösli, M., Sinues, P., Schär, P., Schürmann, D., Rüttimann, C., Da Silva Sena, C. R., Nahum, U., Usemann, J., Steinberg, R., Yammine, S., Schulzke, S., Latzin, P., Frey, U., Beck, F., et al. (2024). Differences in autophagy marker levels at birth in preterm vs. term infants. Pediatric Research, 96(5), 1299–1305. https://doi.org/10.1038/s41390-024-03273-6