Differences in autophagy marker levels at birth in preterm vs. term infants

Background Preterm infants are susceptible to oxidative stress and prone to respiratory diseases. Autophagy is an important defense mechanism against oxidative-stress-induced cell damage and involved in lung development and respiratory morbidity. We hypothesized that autophagy marker levels differ between preterm and term infants. Methods In the prospective Basel-Bern Infant Lung Development (BILD) birth cohort we compared cord blood levels of macroautophagy (Beclin-1, LC3B), selective autophagy (p62) and regulation of autophagy (SIRT1) in 64 preterm and 453 term infants. Results Beclin-1 and LC3B did not differ between preterm and term infants. However, p62 was higher (0.37, 95% confidence interval (CI) 0.05;0.69 in log2-transformed level, p = 0.025, padj = 0.050) and SIRT1 lower in preterm infants (−0.55, 95% CI −0.78;−0.31 in log2-transformed level, padj < 0.001). Furthermore, p62 decreased (padj-value for smoothing function was 0.018) and SIRT1 increased (0.10, 95% CI 0.07;0.13 in log2-transformed level, padj < 0.001) with increasing gestational age. Conclusion Our findings suggest differential levels of key autophagy markers between preterm and term infants. This adds to the knowledge of the sparsely studied field of autophagy mechanisms in preterm infants and might be linked to impaired oxidative stress response, preterm birth, impaired lung development and higher susceptibility to respiratory morbidity in preterm infants. Impact To the best of our knowledge, this is the first study to investigate autophagy marker levels between human preterm and term infants in a large population-based sample in cord blood plasma. This study demonstrates differential levels of key autophagy markers in preterm compared to term infants and an association with gestational age. This may be linked to impaired oxidative stress response or developmental aspects and provide bases for future studies investigating the association with respiratory morbidity

Schlagwörter

Fachgebiet (DDC)

600 - Technik, Medizin, angewandte Wissenschaften

Projekt

Veranstaltung

Startdatum der Ausstellung

Enddatum der Ausstellung

Startdatum der Konferenz

Enddatum der Konferenz

Datum der letzten Prüfung

ISBN

ISSN

0031-3998
1530-0447

Sprache

Englisch

Während FHNW Zugehörigkeit erstellt

Ja

Zukunftsfelder FHNW

Publikationsstatus

Veröffentlicht

Begutachtung

Peer-Review der ganzen Publikation

Open Access-Status

Closed

Lizenz

Zitation

KÜNSTLE, Noëmi, Olga GORLANOVA, Andrea MARTEN, Loretta MÜLLER, Pawan SHARMA, Martin RÖÖSLI, Pablo SINUES, Primo SCHÄR, David SCHÜRMANN, Céline RÜTTIMANN, Carla Rebeca DA SILVA SENA, Uri NAHUM, Jakob USEMANN, Ruth STEINBERG, Sophie YAMMINE, Sven SCHULZKE, Philipp LATZIN, Urs FREY, Fiona BECK, Xenia BOVERMANN, Carmen CASAULTA, Marion CURDY, Carla Rebeca DA SILVA SENA, Kees DE HOOGH, Bettina FRAUCHIGER, Léa Kim-Mi HO DAC, Elisabeth KIENINGER, Insa KORTEN, Marc-Alexander OESTREICH, Benjamin STÖCKLIN, Carmen STREIBEL und Florian WYLER, 2024. Differences in autophagy marker levels at birth in preterm vs. term infants. Pediatric Research. 29 Mai 2024. Bd. 96, Nr. 5, S. 1299–1305. DOI 10.1038/s41390-024-03273-6. Verfügbar unter: https://irf.fhnw.ch/handle/11654/50010

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