Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide
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[Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide_Lucy Kind]
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Publication date
27.03.2017
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01A - Journal article
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Parent work
Journal of Dental Research
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Pages / Duration
1-8
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Abstract
Self-assembling β-sheet forming peptide P11-4 has shown potential in the treatment and prevention of dental caries by supporting tissue regeneration. It has previously been shown that application of monomeric P11-4 solution to early carious lesions can increase net mineral gain by forming de novo hydroxyapatite crystals. The hypothesis for the mode of action was that monomeric self-assembling peptide P11-4 diffuses into the subsurface lesion body and assembles therein into higher order fibrils, facilitating mineralization of the subsurface volume by mimicking the natural biomineralization of the tooth enamel.
Keywords
enamel biomineralization/formation, micro–computed tomography, regeneration, scanning electron microscopy (SEM), dentistry
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ISBN
ISSN
0022-0345
1544-0591
1544-0591
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
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Published
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Citation
Kind, L., Stevanovic, S., Wuttig, S., Wimberger, S., Hofer, J., Müller, B., & Pieles, U. (2017). Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide. Journal of Dental Research, 1–8. https://doi.org/10.1177/0022034517698419