Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles
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Publication date
09.04.2025
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01A - Journal article
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Journal of Materials Chemistry B
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13
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Pages / Duration
5365-5379
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Royal Society of Chemistry
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Abstract
The escalating global threat of antibiotic-resistant bacterial infections, driven by biofilm formation on medical device surfaces, prompts the need for innovative therapeutic strategies. To address this growing challenge, we develop rifampicin-loaded multicompartment micelles (RIF-MCMs) immobilized on surfaces, offering a dual-functional approach to enhance antimicrobial efficacy for localized therapeutic applications. We first optimize the physicochemical properties of RIF-MCMs, and subsequently coat the optimal formulation onto a glass substrate, as confirmed by quartz crystal microbalance and atomic force microscopy. Surface-immobilized RIF-MCMs facilitate sustained antibiotic release in response to biologically relevant temperatures (37 °C and 42 °C). In addition, their heterogeneous distribution enhances the surface's roughness, contributing to the antibacterial activity through passive mechanisms such as hindering bacterial adhesion and biofilm formation. In vitro antimicrobial testing demonstrates that RIF-MCM-modified surfaces achieve a 98% reduction in Staphylococcus aureus viability and a three-order-of-magnitude decrease in colony formation compared to unmodified surfaces. In contrast, RIF-MCMs exhibit minimal cytotoxicity to mammalian cells, making them suitable candidates for medical device coatings. Our dual-function antimicrobial strategy, combining sustained antibiotic release and enhanced surface roughness, presents a promising approach to locally prevent implant-associated infections and biofilm formation.
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2050-750X
2050-7518
2050-7518
Language
English
Created during FHNW affiliation
Yes
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Publication status
Published
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Peer review of the complete publication
Open access category
Hybrid
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Citation
Tarvirdipour, S., Abdollahi, S. N., Köser, J., Bina, M., Schoenenberger, C.-A., & Palivan, C. G. (2025). Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles. Journal of Materials Chemistry B, 13, 5365–5379. https://doi.org/10.1039/d5tb00246j