Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles
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Autor:in (Körperschaft)
Publikationsdatum
09.04.2025
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Journal of Materials Chemistry B
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
13
Ausgabe / Nummer
Seiten / Dauer
5365-5379
Patentnummer
Verlag / Herausgebende Institution
Royal Society of Chemistry
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The escalating global threat of antibiotic-resistant bacterial infections, driven by biofilm formation on medical device surfaces, prompts the need for innovative therapeutic strategies. To address this growing challenge, we develop rifampicin-loaded multicompartment micelles (RIF-MCMs) immobilized on surfaces, offering a dual-functional approach to enhance antimicrobial efficacy for localized therapeutic applications. We first optimize the physicochemical properties of RIF-MCMs, and subsequently coat the optimal formulation onto a glass substrate, as confirmed by quartz crystal microbalance and atomic force microscopy. Surface-immobilized RIF-MCMs facilitate sustained antibiotic release in response to biologically relevant temperatures (37 °C and 42 °C). In addition, their heterogeneous distribution enhances the surface's roughness, contributing to the antibacterial activity through passive mechanisms such as hindering bacterial adhesion and biofilm formation. In vitro antimicrobial testing demonstrates that RIF-MCM-modified surfaces achieve a 98% reduction in Staphylococcus aureus viability and a three-order-of-magnitude decrease in colony formation compared to unmodified surfaces. In contrast, RIF-MCMs exhibit minimal cytotoxicity to mammalian cells, making them suitable candidates for medical device coatings. Our dual-function antimicrobial strategy, combining sustained antibiotic release and enhanced surface roughness, presents a promising approach to locally prevent implant-associated infections and biofilm formation.
Schlagwörter
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
2050-750X
2050-7518
2050-7518
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Hybrid
Lizenz
Zitation
Tarvirdipour, S., Abdollahi, S. N., Köser, J., Bina, M., Schoenenberger, C.-A., & Palivan, C. G. (2025). Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles. Journal of Materials Chemistry B, 13, 5365–5379. https://doi.org/10.1039/d5tb00246j