Polymorph selection by continuous crystallization in the presence of wet milling
Lade...
Dateien
[Author Accepted Manuscript]
Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
04.03.2019
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Crystal Growth & Design
Themenheft
DOI der Originalpublikation
Link
Zugehörige Forschungsdaten
Reihe / Serie
Reihennummer
Jahrgang / Band
19
Ausgabe / Nummer
4
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
American Chemical Society
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The polymorph selection in a continuous crystallization process combined with wet milling is investigated. To this end, a dimensionless population balance equation model accounting for secondary nucleation, crystal growth, and breakage is formulated and solved numerically. We show that a surprisingly small number of dimensionless parameter groups (combinations of kinetic parameters and operating conditions) is decisive in controlling the polymorphic outcome. Specifically, we show how the operating region where the stable polymorph is obtained can be enlarged by tuning the milling intensity, feed concentration, and residence time. We further rationalize the dependence of the mean size of the particles obtained, the fraction of solute recovered, and the productivity of such a process on the dimensionless variables. We showcase this for the model system l-glutamic acid crystallized from water and show that our analysis is in agreement with previously reported experimental studies. Summarizing, the analysis approach introduced here can be used to identify operating spaces for single-stage continuous crystallization processes where the right polymorph is reliably obtained and where size, solute recovery, and productivity are guaranteed to desired levels.
Schlagwörter
Animal feed, Crystallization, Crystals, Separation science, Stability
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1528-7483
1528-7505
1528-7505
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Nein
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Green
Lizenz
Zitation
Li, Y., O’Shea, S., Yin, Q., & Vetter, T. (2019). Polymorph selection by continuous crystallization in the presence of wet milling. Crystal Growth & Design, 19(4). https://doi.org/10.1021/acs.cgd.8b01894