Toothpastes with enzymes support gum health and reduce plaque formation
Authors
Paque, Pune
Schmidlin, Patrick
Wiedemeier, Daniel
Wegehaupt, Florian
Burrer, Phoebe
Körner, Philipp
Deari, Shengjile
Attin, Thomas
Author (Corporation)
Publication date
19.01.2021
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
International Journal of Environmental Research and Public Health
Special issue
DOI of the original publication
Link
Series
Series number
Volume
18
Issue / Number
835
Pages / Duration
1-14
Patent number
Publisher / Publishing institution
MDPI
Place of publication / Event location
Basel
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study tested the antimicrobial potential of different enzyme-containing toothpaste formulations. Two promising formulations (enzyme-containing toothpastes with glucose oxidase and D-glucose with (C+) and without Citrox (C−) Citrox) were investigated in a clinical crossover trial (two slurries: sodium lauryl sulfate-containing (SLS), a toothpaste without SLS (reference), and water). Subjects (n = 20) abstained from toothbrushing for four days and rinsed with a toothpaste slurry. Bleeding on probing (BOP) and plaque indices (PI) were measured. A mixed linear model was used to statistically compare the slurries with respect to BOP and PI change. The in vitro bacterial growth-inhibiting evaluation showed the best results for SLS, followed by C+ and C−. The change in BOP and PI exhibited statistically significant differences to water rinsing (BOP; PI changes in % points (difference of the baseline and post-rinse values: water = 8.8%; 90.0%; C+ = −1.4%; 80.4%; SLS = 1.5%; 72.1%; reference = 0.8%; 77.5%; C− = −1.8%; 75.1%). All slurries exhibited anti-gingivitis and anti-plaque effects, resulting in a prophylactic benefit for limited-access regions during brushing.
Keywords
Gingiva, Toothbrushing, Dentifrice, Prophylaxis, Prevention, Bacteria, Gingivitis, Low responder, High responder
Subject (DDC)
Event
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ISBN
ISSN
1661-7827
1660-4601
1660-4601
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
License
Citation
PAQUE, Pune, Patrick SCHMIDLIN, Daniel WIEDEMEIER, Florian WEGEHAUPT, Phoebe BURRER, Philipp KÖRNER, Shengjile DEARI, Michel SCIOTTI und Thomas ATTIN, 2021. Toothpastes with enzymes support gum health and reduce plaque formation. International Journal of Environmental Research and Public Health. 19 Januar 2021. Bd. 18, Nr. 835, S. 1–14. DOI 10.3390/ijerph18020835. Verfügbar unter: https://doi.org/10.26041/fhnw-4127