Label free detection of biomolecular interactions

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Authors
Author (Corporation)
Publication date
2005
Type of student thesis
Course of study
Collections
Institute for Medical Engineering and Medical Informatics
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Type
04B - Conference paper
Editors
Editor (Corporation)
Supervisor
Parent work
IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference, 2005.
Special issue
DOI of the original publication
https://doi.org/10.1109/omems.2005.1540087
URI
https://irf.fhnw.ch/handle/11654/46769
Link
Related research data
Series
Series number
Volume
Issue / Number
Pages / Duration
81-82
Patent number
Publisher / Publishing institution
IEEE
Place of publication / Event location
Oulu
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
This work presents a simple evanescent wave sensing system based on an interferometric approach suitable to meet the demands on label free sensor systems for the detection of biomolecular interactions especially. It is representing a basic concept towards high throughput application. The system performance and reproducibility was evaluated with refractometric measurements of sucrose dilutions. A mean resolution of the effective refractive index of 3sigma(Deltamacrnmacr eff )=0.9middot10 -6 without averaging and a reproducibility below sigma r =0.1middot10 -6 were achieved. The suitability for the detection of biomolecular interactions was validated with the detection of a DNA hybridization
Keywords
Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Project
Event
IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference
Exhibition start date
Exhibition end date
Conference start date
01.08.2005
Conference end date
04.08.2005
Date of the last check
ISBN
0-7803-9278-7
2160-5033
2160-5041
ISSN
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
peer-reviewed
Open access category
Closed
License
Citation
Hradetzky, D., Müller, C., & Reinecke, H. (2005). Label free detection of biomolecular interactions. IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference, 2005., 81–82. https://doi.org/10.1109/omems.2005.1540087
Full item page