Label free detection of biomolecular interactions

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Authors
Author (Corporation)
Publication date
2005
Typ of student thesis
Course of study
Collections
Institut für Medizintechnik und Medizininformatik
Full item page
Type
04B - Conference paper
Editors
Editor (Corporation)
Supervisor
Parent work
IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference, 2005.
Special issue
DOI of the original publication
https://doi.org/10.1109/omems.2005.1540087
URI
https://irf.fhnw.ch/handle/11654/46769
Link
Series
Series number
Volume
Issue / Number
Pages / Duration
81-82
Patent number
Publisher / Publishing institution
IEEE
Place of publication / Event location
Oulu
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
This work presents a simple evanescent wave sensing system based on an interferometric approach suitable to meet the demands on label free sensor systems for the detection of biomolecular interactions especially. It is representing a basic concept towards high throughput application. The system performance and reproducibility was evaluated with refractometric measurements of sucrose dilutions. A mean resolution of the effective refractive index of 3sigma(Deltamacrnmacr eff )=0.9middot10 -6 without averaging and a reproducibility below sigma r =0.1middot10 -6 were achieved. The suitability for the detection of biomolecular interactions was validated with the detection of a DNA hybridization
Keywords
Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Project
Event
IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference
Exhibition start date
Exhibition end date
Conference start date
01.08.2005
Conference end date
04.08.2005
Date of the last check
ISBN
0-7803-9278-7
2160-5033
2160-5041
ISSN
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
License
Citation
Hradetzky, D., Müller, C., & Reinecke, H. (2005). Label free detection of biomolecular interactions. IEEE/LEOS International Conference on Optical MEMS and Their Applications Conference, 2005., 81–82. https://doi.org/10.1109/omems.2005.1540087
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