Probabilistic stimulation mapping from intra-operative thalamic deep brain stimulation data in essential tremor
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Publication date
17.05.2024
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01A - Journal article
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Journal of Neural Engineering
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21
Issue / Number
3
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IOP Publishing
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Abstract
Deep brain stimulation (DBS) is a therapy for Parkinson's disease (PD) and essential tremor (ET). The mechanism of action of DBS is still incompletely understood. Retrospective group analysis of intra-operative data recorded from ET patients implanted in the ventral intermediate nucleus of the thalamus (Vim) is rare. Intra-operative stimulation tests generate rich data and their use in group analysis has not yet been explored. Objective. To implement, evaluate, and apply a group analysis workflow to generate probabilistic stimulation maps (PSMs) using intra-operative stimulation data from ET patients implanted in Vim. Approach. A group-specific anatomical template was constructed based on the magnetic resonance imaging scans of 6 ET patients and 13 PD patients. Intra-operative test data (total: n = 1821) from the 6 ET patients was analyzed: patient-specific electric field simulations together with tremor assessments obtained by a wrist-based acceleration sensor were transferred to this template. Occurrence and weighted mean maps were generated. Voxels associated with symptomatic response were identified through a linear mixed model approach to form a PSM. Improvements predicted by the PSM were compared to those clinically assessed. Finally, the PSM clusters were compared to those obtained in a multicenter study using data from chronic stimulation effects in ET. Main results. Regions responsible for improvement identified on the PSM were in the posterior sub-thalamic area (PSA) and at the border between the Vim and ventro-oral nucleus of the thalamus (VO). The comparison with literature revealed a center-to-center distance of less than 5 mm and an overlap score (Dice) of 0.4 between the significant clusters. Our workflow and intra-operative test data from 6 ET-Vim patients identified effective stimulation areas in PSA and around Vim and VO, affirming existing medical literature. Significance. This study supports the potential of probabilistic analysis of intra-operative stimulation test data to reveal DBS's action mechanisms and to assist surgical planning.
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1741-2560
1741-2552
1741-2552
Language
English
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Yes
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Publication status
Published
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Peer review of the complete publication
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Hybrid
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Citation
Vogel, D., Nordin, T., Feiler, S., Wårdell, K., Coste, J., Lemaire, J.-J., & Hemm-Ode, S. (2024). Probabilistic stimulation mapping from intra-operative thalamic deep brain stimulation data in essential tremor. Journal of Neural Engineering, 21(3). https://doi.org/10.1088/1741-2552/ad4742