Analysis of the physical characteristics of an anhydrous vehicle for compounded pediatric oral liquids

dc.contributor.authorBanov, Daniel
dc.contributor.authorLiu, Yi
dc.contributor.authorIp, Kendice
dc.contributor.authorShan, Ashley
dc.contributor.authorVu, Christine
dc.contributor.authorZdoryk, Oleksandr
dc.contributor.authorBassani, August S.
dc.contributor.authorCarvalho, Maria
dc.date.accessioned2024-02-08T09:40:54Z
dc.date.available2024-02-08T09:40:54Z
dc.date.issued2023
dc.description.abstract<jats:p>The paucity of suitable drug formulations for pediatric patients generates a need for customized, compounded medications. This research study was set out to comprehensively analyze the physical properties of the new, proprietary anhydrous oral vehicle SuspendIt® Anhydrous, which was designed for compounding pediatric oral liquids. A wide range of tests was used, including sedimentation volume, viscosity, droplet size after dispersion in simulated gastric fluid, microscopic examination and content uniformity measurements to evaluate the properties of the anhydrous vehicle. The results showed that the vehicle exhibited consistent physical properties under varying conditions and maintained stability over time. This can be attributed to the unique blend of excipients in its formulation, which not only maintain its viscosity but also confer thixotropic behavior. The unique combination of viscous, thixotropic and self-emulsifying properties allows for rapid redispersibility, sedimentation stability, accurate dosing, potential drug solubility, dispersion and promotion of enhanced gastrointestinal distribution and absorption. Furthermore, the vehicle demonstrated long-term sedimentation stability and content uniformity for a list of 13 anhydrous suspensions. These results suggest that the anhydrous oral vehicle could serve as a versatile base for pediatric formulation, potentially filling an important gap in pediatric drug delivery. Future studies can further investigate its compatibility, stability and performance with other drugs and in different clinical scenarios.</jats:p>
dc.identifier.doi10.3390/pharmaceutics15112642
dc.identifier.issn1999-4923
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/44016
dc.identifier.urihttps://doi.org/10.26041/fhnw-7914
dc.issue11
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofPharmaceutics
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAnalysis of the physical characteristics of an anhydrous vehicle for compounded pediatric oral liquids
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume15
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.openAccessCategoryGold
fhnw.publicationStatePublished
relation.isAuthorOfPublicationb83b2aa7-d9e1-498a-89be-67530496569c
relation.isAuthorOfPublication.latestForDiscoveryb83b2aa7-d9e1-498a-89be-67530496569c
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