Biomimetic 3D-printed gyroid scaffolds with versatile bioactive coatings for complex craniomaxillofacial bone regeneration
Loading...
Author (Corporation)
Publication date
2026
Type of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Biomedical Materials
Special issue
DOI of the original publication
Link
Related research data
Series
Series number
Volume
21
Issue / Number
3
Pages / Duration
035001
Patent number
Publisher / Publishing institution
IOP Publishing
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
Three-dimensional (3D) printing enables the fabrication of biomimetic scaffolds for craniomaxillofacial (CMF) bone regeneration, offering patient-specific solutions with tailored mechanical and biological properties. This study presents a 3D-printed gyroid scaffold composed of poly(L-lactide-co-D,L-lactide) (PLDLLA) and β -tricalcium phosphate ( β -TCP), designed to enhance structural integrity and bioactivity. Using computer-aided design (CAD) and a dual-material additive manufacturing approach incorporating a water-soluble support material, scaffolds with controlled porosity and tunable mechanical properties are fabricated to match trabecular mandibular bone characteristics. Mechanical testing demonstrates that modulating wall thickness and porosity optimizes compressive strength and elastic modulus, ensuring stability under physiological loads. Chemical and cytotoxicity analyses confirm biocompatibility across manufacturing, post-processing, and sterilization. Biofunctionalization with polydopamine (PDA) and nano-hydroxyapatite (nHAP) enables selective cellular responses. PDA suppresses cell mineralization markers in osteosarcoma cells, while PDA-nHAP enhances osteogenic differentiation and fibroblast adhesion, supporting regenerative applications. High fidelity to CAD models and suitability for point-of-care fabrication underscore its clinical potential for CMF defect repair. By integrating tunable mechanics and targeted bioactivity, the developed scaffold offers a versatile platform for CMF reconstruction, addressing critical challenges in bone tissue engineering.
Keywords
Event
Exhibition start date
Exhibition end date
Conference start date
Conference end date
Date of the last check
ISBN
ISSN
1748-6041
1748-605X
1748-605X
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
peer-reviewed
Open access category
Hybrid
License
Citation
Tourbier, C., Basoli, V., Maintz, M., Bella, E. D., Stoddart, M. J., & Thieringer, F. M. (2026). Biomimetic 3D-printed gyroid scaffolds with versatile bioactive coatings for complex craniomaxillofacial bone regeneration. Biomedical Materials, 21(3), 35001. https://doi.org/10.1088/1748-605x/ae55ed