Design of miniaturized electro spray instrument for gene and drug therapeutic treatment of IPF
Loading...
Author (Corporation)
Publication date
2013
Typ of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Biomedical Engineering / Biomedizinische Technik
Special issue
DOI of the original publication
Link
Series
Series number
Volume
85
Issue / Number
1
Pages / Duration
Patent number
Publisher / Publishing institution
De Gruyter
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
Electric field accelerated plasmid droplets to permeate tissues has been demonstrated on cell culture and ex-vivo lung tissue of rats using enhanced green fluorescence protein reporter gene for transfection. This opens a window of opportunity to design an electrospray instrument usable within the working channel of bronchoscope to noninvasively treat idiopathic pulmonary fibrosis (IPF). We elaborate a concept and realized a device usable in the working channel of a flexible bronchoscope taking into account restrictions within typical bronchoscopy procedure.
Keywords
Gene delivery method, Idiopathic pulmonary fibriosis, Bronchoscopy
Subject (DDC)
Event
Exhibition start date
Exhibition end date
Conference start date
Conference end date
Date of the last check
ISBN
ISSN
1862-278X
0013-5585
0013-5585
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
License
Citation
Fiave, P. A., Boehringer, S., Gazdhar, A., Geiser, T., & Hradetzky, D. (2013). Design of miniaturized electro spray instrument for gene and drug therapeutic treatment of IPF. Biomedical Engineering / Biomedizinische Technik, 85(1). https://doi.org/10.1515/bmt-2013-4041