Comparison of methods for phylogenetic B-cell lineage inference using time-resolved antibody repertoire simulations (AbSim)

Type
01A - Journal article
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Parent work
Bioinformatics
Special issue
DOI of the original publication
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Series number
Volume
33
Issue / Number
24
Pages / Duration
3938-3946
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Publisher / Publishing institution
Oxford University Press
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Abstract
Motivation: The evolution of antibody repertoires represents a hallmark feature of adaptive B-cell immunity. Recent advancements in high-throughput sequencing have dramatically increased the resolution to which we can measure the molecular diversity of antibody repertoires, thereby offering for the first time the possibility to capture the antigen-driven evolution of B cells. However, there does not exist a repertoire simulation framework yet that enables the comparison of com monly utilized phylogenetic methods with regard to their accuracy in inferring antibody evolution.
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ISBN
ISSN
1367-4803
1367-4811
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
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Citation
Yermanos, A., Greiff, V., Krautler, N. J., Menzel, U., Dounas, A., Miho, E., Oxenius, A., Stadler, T., & Reddy, S. T. (2017). Comparison of methods for phylogenetic B-cell lineage inference using time-resolved antibody repertoire simulations (AbSim). Bioinformatics, 33(24), 3938–3946. https://doi.org/10.1093/bioinformatics/btx533