Dynemicin analogs: Syntheses, methods of preparation and use

A fused ring system compound is disclosed that contains an epoxide group on one side or the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bounded to (i) a sugar moiety as the ogligosaccharide portion or(ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods or preparing a compound.

Schlagwörter

Fachgebiet (DDC)

540 - Chemie
570 - Biowissenschaften, Biologie

Projekt

Veranstaltung

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Enddatum der Konferenz

Datum der letzten Prüfung

ISBN

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Sprache

Während FHNW Zugehörigkeit erstellt

Nein

Zukunftsfelder FHNW

Publikationsstatus

Begutachtung

Open Access-Status

Lizenz

Zitation

Smith, A. L., Hwang, C.-K., Wendeborn, S., Nicolaou, K. C., Schreiner, E. P., Stahl, W., Dai, W.-M., Maligres, P. E., & Suzuki, T. (1994). Dynemicin analogs: Syntheses, methods of preparation and use. United States Patent and Trademark Office. https://doi.org/10.26041/fhnw-9890

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