Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine
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Authors
Delaval, Mathilde N.
Jonsdottir, Hulda R.
Leni, Zaira
Brem, Benjamin T.
Siegerist, Frithjof
Schönenberger, David
Durdina, Lukas
Elser, Miriam
Salathe, Matthias
Author (Corporation)
Publication date
15.08.2022
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Type
01A - Journal article
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Parent work
Environmental Pollution
Special issue
DOI of the original publication
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Series
Series number
Volume
307
Issue / Number
Pages / Duration
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Publisher / Publishing institution
Elsevier
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Abstract
Health effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto reconstituted human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine was evaluated under realistic engine conditions by sampling and exposing HBE derived from donors of normal and compromised health status to exhaust for 1 h followed by biomarker analysis 24 h post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 109 particles cm−2 or 337.1 ng cm−2. Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings.
Keywords
Aerosol, Aircraft engine exhaust, Bronchial epithelial cell culture, Cellular response, Non-volatile particulate matter
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ISBN
ISSN
1873-6424
0269-7491
0269-7491
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
License
Citation
Delaval, M. N., Jonsdottir, H. R., Leni, Z., Keller, A., Brem, B. T., Siegerist, F., Schönenberger, D., Durdina, L., Elser, M., Salathe, M., Baumlin, N., Lobo, P., Burtscher, H., Liati, A., & Geiser, M. (2022). Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine. Environmental Pollution, 307. https://doi.org/10.1016/j.envpol.2022.119521