Synthesis of grignard reagents using mechanochemistry
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Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
2026
Typ der Arbeit
Bachelor
Studiengang
Bachelor of Science FHNW in Life Sciences BSLS
Typ
11 - Studentische Arbeit
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Themenheft
DOI der Originalpublikation
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Zugehörige Forschungsdaten
Reihe / Serie
Reihennummer
Jahrgang / Band
Ausgabe / Nummer
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Hoschule für Life Sciences FHNW
Verlagsort / Veranstaltungsort
Muttenz
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Willy A. Bachofen AG
Zusammenfassung
Introduction: The Grignard reaction remains widely used in industry for C–C coupling but carries inherent safety concerns. Delayed initiation and stalled reactions, both caused by the passivating oxide layer on the magnesium, can release the accumulated reaction heat rapidly and destabilize the reaction mixture thermally [1]. Several technologies address these concerns. Flow processes such as packed magnesium bed reactors lower the reactive inventory compared to classical semi-batch operation [2]. Mechanochemistry instead facilitates Grignard formation by mechanical activation of the magnesium [3]. Bead milling, closely related to ball milling, uses microbeads that enhance the reaction properties at high rotational speeds and has recently been applied to a more sustainable amide bond formation [4].
Objective: This work aims to develop a bead mill Grignard process that improves safety through mechanical magnesium activation and continuous processing. Benzyl chloride was chosen as an exemplary substrate, as it is known for its pronounced tendency towards side product formation. The process is transferred from Semi-batch operation to, ultimately, a Single-pass mode, accompanied throughout by a safety assessment. Selectivity serves as the key indicator for comparing the operating modes.
Schlagwörter
Mechanochemistry, Grignard, Process safety, Process optimization
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Begutachtung
Open Access-Status
Lizenz
Zitation
Marti, M. (2026). Synthesis of grignard reagents using mechanochemistry [Hoschule für Life Sciences FHNW]. https://doi.org/10.26041/fhnw-17816