Neueste Zugänge

  • Metabolomic serum abnormalities in dogs with hepatopathies 

    Imbery, Carolin A.; Dieterle, Frank; Ottka, Claudia; Weber, Corinna; Müller, Elisabeth; Lohi, Hannes; Giger, Urs; Schlotterbeck, Götz (2022-03-29)
    Scientific Reports
    Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Modeling-Based Approach Towards Quality by Design for a Telescoped Process 

    Zogg, Andreas; Zahnd, This (2022)
    A synthesis step, consisting of two sub-steps A and B was investigated by applying a model based approach. Deepening the process understanding was achieved through performed experiments, which also led to the generation ...
    11 - Studentische Arbeit
  • Electrochemical membrane-assisted pH-swing extraction and back-extraction of lactic acid 

    Gausmann, Marcel; Bertram, Franziska; Schuur, Boelo; Jupke, Andreas; Gössi, Angelo; Riedl, Wolfgang (2022)
    Separation and Purification Technology
    Reactive extraction of carboxylic acids such as lactic acid with tertiary amines is a state-of-the-art process but suffers strongly from reduced extraction efficiency in buffered environments like fermentation broths. In ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Evaluation of dioxin induced transcriptomic responses in a 3D human liver microtissue model 

    Tian, Mingming; Gou, Xiao; Zhang, Xiaowei; Messner, Catherine; Suter-Dick, Laura; Yan, Lu (2022)
    Environmental Research
    Three-dimensional human liver microtissue model provides a promising method for predicting the human hepatotoxicity of environmental chemicals. However, the dynamics of transcriptional responses of 3D human liver microtissue ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • How to Foster ‘New Approach Methodology’ Toxicologists 

    Doktorova, Tatyana Y.; Azzi, Pamela; Hofer, Joelle; Werner, Sophie; Singh, Pranika; Hardy, Barry; Chesne, Christophe; Messner, Catherine; Gaiser, Carine; Suter-Dick, Laura (2022-02-18)
    Alternatives to Laboratory Animals
    The need to reduce, refine and replace animal experimentation has led to a boom in the establishment of new approach methodologies (NAMs). This promising trend brings the hope that the replacement of animals by using NAMs ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Mass transfer analysis and kinetic modeling for process design of countercurrent membrane supported reactive extraction of carboxylic acids 

    Schuur, Boelo; Gössi, Angelo; Riedl, Wolfgang (2021)
    Chemical Engineering Science: X
    Countercurrent membrane supported reactive extraction (MSRE) was studied for removal of carboxylic acids from aqueous streams with a PTFE capillary membrane. Analysis of the mass transfer rates was per- formed to support ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism 

    Imbery, Carolin Anna; Dieterle, Frank; Ottka, Claudia; Weber, Corinna; Müller, Elisabeth; Lohi, Hannes; Giger, Urs; Schlotterbeck, Götz (2022-04-09)
    Metabolites
    The adrenal glands play a major role in metabolic processes, and both excess and insufficient serum cortisol concentrations can lead to serious metabolic consequences. Hyper- and hypoadrenocorticism represent a diagnostic ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Novel Titanium Nanospike Structure Using Low-Energy Helium Ion Bombardment for the Transgingival Part of a Dental Implant 

    Mukaddam, Khaled; Astasov-Frauenhoffer, Monika; Fasler-Kan, Elizaveta; Marot, Laurent; Kisiel, Marcin; Steiner, Roland; Sanchez, Fabien; Meyer, Ernst; Bornstein, Michael M.; Kühl, Sebastian; Köser, Joachim (2022-03-24)
    Nanomaterials
    Aim(s): The aim of the study was to fabricate a nanospike surface on a titanium alloy surface using a newly established method of low-energy helium ion bombardment. Various methods to achieve nanospike formation on titanium ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Using GPCRs as molecular beacons to target ovarian cancer with nanomedicines 

    Khetan, Riya; Dharmayanti, Cintya; Gillam, Todd A.; Kübler, Eric; Klingler-Hoffmann, Manuela; Ricciardelli, Carmela; Oehler, Martin K.; Blencowe, Anton; Garg, Sanjay; Albrecht, Hugo (2022-05-10)
    Cancers
    The five-year survival rate for women with ovarian cancer is very poor despite radical cytoreductive surgery and chemotherapy. Although most patients initially respond to platinum-based chemotherapy, the majority experience ...
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • New Scale-Up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants 

    Zogg, Andreas; Furrer, Thierry (2022)
    05 - Forschungs- oder Arbeitsbericht
  • Biological properties of extracellular vesicles and their physiological functions 

    Lipps, Georg (2015-05-14)
    Journal of Extracellular Vesicles
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study 

    Cuenod, Aline; Wüthrich, Daniel; Seth-Smith, Helena; Ott, Chantal; Gehringer, Christian; Foucaul, Frederic; Mouchet, Roxanne; Kassim, Ali; Revathi, Gunturu; Vogt, Deborah; von Felten, Stefanie; Bassetti, Stefano; Tschudin-Sutter, Sarah; Hettich, Timm; Schlotterbeck, Götz; Homberger, Christina; Casanova, Carlo; Moran-Gilad, Jakob; Sagi, Orli; Rodriguez-Sanchez, Belen; Müller, Franco; Aerni, Martina; Gaia, Valeria; van Dessel, Helke; Kampinga, Greetje; Müller, Claudia; Daubenberger, Claudia; Pflüger, Valentin; Egli, Adrian (2021)
    Genome Medicine
    Background Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Self-assembly and magnetic order of bi-molecular 2D spin lattices of M(II,III) Phthalocyanines on Au(111) 

    Liu, Xiunshan; Popova, Olha; Girovsky, Jan; Nowakowski, Jan; Rossmann, Harald; Nijs, Thomas; Moradi, Mina; Mousavi, Fatemeh; Plumb, Nicholas; Radovic, Milan; Ballav, Nirmalya; Dreiser, Jan; Decurtins, Silvio; Pasti, Igor; Skorodumova, Natalia; Liu, Shi-Xia; Jung, Thomas A; Baljozovic, Milos (2021-08-19)
    magnetochemistry
    Single layer low-dimensional materials are presently of emerging interest, including in the context of magnetism. In the present report, on-surface supramolecular architecturing was further developed and employed to create ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Coordination-driven monolayer-to-bilayer transition in two-dimensional metal–organic networks 

    Moradi, Mina; Lengweiler, Nadia; Housecroft, Catherine; Tulli, Ludovico; Stahlberg, Henning; Jung, Thomas; Shahgaldian, Patrick (2021-03-16)
    The Journal of Physical Chemistry B
    We report on monolayer-to-bilayer transitions in 2D metal–organic networks (MONs) from amphiphiles supported at the water–air interface. Functionalized calix[4]arenes are assembled through the coordination of selected ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Development of a unique rapid test to detect anti-bodies directed against an extended RBD of SARS-CoV-2 spike protein 

    Brosi, Larissa; Villiger, Thomas; Bantleon, Frank; Melone, Anna; Überschlag, Marie-Eve; Dolce, Daniele; Giegelmann, Cedric; Gerspach, Michael; Dirscherl, Lorin; Panikulam, Sherin; Romann, Patrick; Weston, Anna; Kübler, Eric; Gerhold, Christian (2021-05-28)
    Chimia
    Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Expanding the potential of the solvent-assisted method to create bio-interfaces from amphiphilic block copolymers 

    Di Leone, Stefano; Vallapurackal, Jaicy; Yorulmaz Avsar, Saziye; Kyropolou, Myrto; Ward, Thomas; Palivan, Cornelia; Meier, Wolfgang (2021-06-09)
    Biomacromolecules
    Artificial membranes, as materials with biomimetic properties, can be applied in various fields, such as drug screening or bio-sensing. The solvent-assisted method (SA) represents a straightforward method to prepare lipid ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity 

    Bordier, Valentine; Teysseire, Fabienne; Schlotterbeck, Götz; Beglinger, Christoph; Meyer-Gerspach, Anne-Christin; Wölnerhanssen, Bettina; Senner, Frank (2021-11-05)
    nutrients
    In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute in- gestion reduces ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Automated chiral method screening. Evaluation of generated chromatographic data sets to further optimize screening efficiency 

    Freund, Ernst; Meyer, Daniel; Schneider, Nadine; Lozach, Marie-Anne; Schröder, Harald; Cinar, Catagay; Schlotterbeck, Götz; Wagner, Trixie (2021-05-10)
    Journal of Chromatography A
    We set up an automated screening process to routinely test 10 chiral supercritical fluid chromatography (SFC) methods - five columns combined with two co-solvents - as part of a chiral separation lab workflow. Proprietary ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Toothpastes with enzymes support gum health and reduce plaque formation 

    Paque, Pune; Schmidlin, Patrick; Wiedemeier, Daniel; Wegehaupt, Florian; Burrer, Phoebe; Körner, Philipp; Deari, Shengjile; Sciotti, Michel; Attin, Thomas (2021-01-19)
    International Journal of Environmental Research and Public Health
    Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Spectrophotometric study of the interaction of active pharmaceutical ingredients with colloidal silver nanoparticles capped by sulfonato-calix[6]arene derivatives 

    Montasser, Imed; Robert, Paul; Hafiane, Amor; Correro, Maria Rita; Shahgaldian, Patrick (2021-02-13)
    Materials technology
    Three sulfonato-calix[6]arene derivatives, namely para-sulfonato-calix[6]arene, calix[6]arene-O-propyl-3-sulphonate and para-sulfonato-calix[6]arene-O-propyl-3-sulphonate have been used as capping agents for silver ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin

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