Neueste Zugänge

  • New Scale-Up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants 

    Zogg, Andreas; Furrer, Thierry (2022)
    05 - Forschungs- oder Arbeitsbericht
  • Biological properties of extracellular vesicles and their physiological functions 

    Lipps, Georg (2015-05-14)
    Journal of Extracellular Vesicles
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of Klebsiella oxytoca group in invasive infections: a retrospective clinical study 

    Cuenod, Aline; Wüthrich, Daniel; Seth-Smith, Helena; Ott, Chantal; Gehringer, Christian; Foucaul, Frederic; Mouchet, Roxanne; Kassim, Ali; Revathi, Gunturu; Vogt, Deborah; von Felten, Stefanie; Bassetti, Stefano; Tschudin-Sutter, Sarah; Hettich, Timm; Schlotterbeck, Götz; Homberger, Christina; Casanova, Carlo; Moran-Gilad, Jakob; Sagi, Orli; Rodriguez-Sanchez, Belen; Müller, Franco; Aerni, Martina; Gaia, Valeria; van Dessel, Helke; Kampinga, Greetje; Müller, Claudia; Daubenberger, Claudia; Pflüger, Valentin; Egli, Adrian (2021)
    Genome Medicine
    Background Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Self-assembly and magnetic order of bi-molecular 2D spin lattices of M(II,III) Phthalocyanines on Au(111) 

    Liu, Xiunshan; Popova, Olha; Girovsky, Jan; Nowakowski, Jan; Rossmann, Harald; Nijs, Thomas; Moradi, Mina; Mousavi, Fatemeh; Plumb, Nicholas; Radovic, Milan; Ballav, Nirmalya; Dreiser, Jan; Decurtins, Silvio; Pasti, Igor; Skorodumova, Natalia; Liu, Shi-Xia; Jung, Thomas A; Baljozovic, Milos (2021-08-19)
    Single layer low-dimensional materials are presently of emerging interest, including in the context of magnetism. In the present report, on-surface supramolecular architecturing was further developed and employed to create ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Coordination-driven monolayer-to-bilayer transition in two-dimensional metal–organic networks 

    Moradi, Mina; Lengweiler, Nadia; Housecroft, Catherine; Tulli, Ludovico; Stahlberg, Henning; Jung, Thomas; Shahgaldian, Patrick (2021-03-16)
    The Journal of Physical Chemistry B
    We report on monolayer-to-bilayer transitions in 2D metal–organic networks (MONs) from amphiphiles supported at the water–air interface. Functionalized calix[4]arenes are assembled through the coordination of selected ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Development of a unique rapid test to detect anti-bodies directed against an extended RBD of SARS-CoV-2 spike protein 

    Brosi, Larissa; Villiger, Thomas; Bantleon, Frank; Melone, Anna; Überschlag, Marie-Eve; Dolce, Daniele; Giegelmann, Cedric; Gerspach, Michael; Dirscherl, Lorin; Panikulam, Sherin; Romann, Patrick; Weston, Anna; Kübler, Eric; Gerhold, Christian (2021-05-28)
    Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for an elicited humoral immune response, ideally conferring immunity ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Expanding the potential of the solvent-assisted method to create bio-interfaces from amphiphilic block copolymers 

    Di Leone, Stefano; Vallapurackal, Jaicy; Yorulmaz Avsar, Saziye; Kyropolou, Myrto; Ward, Thomas; Palivan, Cornelia; Meier, Wolfgang (2021-06-09)
    Artificial membranes, as materials with biomimetic properties, can be applied in various fields, such as drug screening or bio-sensing. The solvent-assisted method (SA) represents a straightforward method to prepare lipid ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity 

    Bordier, Valentine; Teysseire, Fabienne; Schlotterbeck, Götz; Senner, Frank; Beglinger, Christoph; Meyer-Gerspach, Anne-Christin; Wölnerhanssen, Bettina (2021-11-05)
    In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute in- gestion reduces ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Automated chiral method screening. Evaluation of generated chromatographic data sets to further optimize screening efficiency 

    Freund, Ernst; Meyer, Daniel; Schneider, Nadine; Lozach, Marie-Anne; Schröder, Harald; Cinar, Catagay; Schlotterbeck, Götz; Wagner, Trixie (2021-05-10)
    Journal of Chromatography A
    We set up an automated screening process to routinely test 10 chiral supercritical fluid chromatography (SFC) methods - five columns combined with two co-solvents - as part of a chiral separation lab workflow. Proprietary ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Toothpastes with enzymes support gum health and reduce plaque formation 

    Paque, Pune; Schmidlin, Patrick; Wiedemeier, Daniel; Wegehaupt, Florian; Burrer, Phoebe; Körner, Philipp; Deari, Shengjile; Sciotti, Michel; Attin, Thomas (2021-01-19)
    International Journal of Environmental Research and Public Health
    Enzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Spectrophotometric study of the interaction of active pharmaceutical ingredients with colloidal silver nanoparticles capped by sulfonato-calix[6]arene derivatives 

    Montasser, Imed; Robert, Paul; Hafiane, Amor; Correro, Maria Rita; Shahgaldian, Patrick (2021-02-13)
    Materials technology
    Three sulfonato-calix[6]arene derivatives, namely para-sulfonato-calix[6]arene, calix[6]arene-O-propyl-3-sulphonate and para-sulfonato-calix[6]arene-O-propyl-3-sulphonate have been used as capping agents for silver ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as fibrosis-specific extracellular biomarkers and promoters of HSC activation 

    Suter-Dick, Laura; Messner, Catherine; Özkul, Dilek; Gaiser, Carine; Schmidt, Saskia; Terraciano, Luigi; Krähenbühl, Stephan (2021)
    International Journal of Molecular Sciences
    Liver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in the formation of fibrous scars. In the clinic, liver biopsies are the standard diagnostic method despite the potential for ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Stringent primer termination by an archaeo-eukaryotic DNA primase 

    Lipps, Georg; Bergsch, Jan; Devillier, Jean-Christophe; Jeschke, Gunnar (2021-04-13)
    Frontiers in Microbiology : Biology of archaea
    Priming of single stranded templates is essential for DNA replication. In recent years, significant progress was made in understanding how DNA primase fulfils this fundamental function, particularly with regard to the ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Nephroscreen. A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment 

    Suter-Dick, Laura; Vriend, Jelle; Vormann, Marianne; Lanz, Henriette; Joore, Jos; Trietsch, Sebastiaan; Russel, Frans; Jacobsen, Björn; Roth, Adrian; Lu, Shuyan; Polli, Joseph; Naidoo, Anita; Masereeuw, Rosalinde; Wilmer, Martijn (2021-03)
    Current Opinion in Toxicology
    Proximal tubule epithelial cells are the main driver of renal transport and secretion of xenobiotics, making them susceptible to drug-induced kidney injury. Cell-based assays are a meaningful alternative to animal testing ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Membrane-supported liquid-liquid extraction. Where do we stand today? 

    Riedl, Wolfgang (2021-02)
    ChemBioEng Reviews
    Thanks to advances in materials science and manufacturing technology, membranes are now available for stable liquid-liquid extraction processes. Rigorous calculation models can be used to calculate the membrane areas ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • High efficient photocatalytic reduction of nitrate to N2 by Core-shell Ag/SiO2@cTiO2 with synergistic effect of light scattering and surface plasmon resonance 

    Corvini, Philippe; Hou, Ziang; Chu, Jiangfeng; Liu, Cong; Wang, Jinnan; Li, Aimin; Lin, Tong (2021-07-01)
    Chemical Engineering Journal
    Photocatalytic denitrification has attracted great attention owing to its high efficiency and environmentally friendly features. However, selectively photocatalytic reduction of high concentration nitrate to N2 is still a ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Deep-bed filters as post-treatment for ozonation in tertiary municipal wastewater treatment. Impact of design and operation on treatment goals 

    Wintgens, Thomas; Sauter, Daniel; Dabrowska, Agata; Bloch, Robert; Stapf, Michael; Miehe, Ulf; Sperlich, Alexander; Gnirss, Regina (2021)
    Environmental Science.Water, Research & Technology
    Ozonation followed by biological post-treatment is an established technology for abatement of organic micropollutants (OMP) from municipal wastewater. Although the necessity of biological post-treatment for oxidation ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Implementation of a human renal proximal tubule on a chip for nephrotoxicity and drug interaction studies 

    Suter-Dick, Laura; Caj, Michaela; Hutter, Simon; Vormann, Marianne; Vriend, Jelle; Lanz, Henriette; Gijzen, Linda; van den Heuvel, Angelique; Joore, Jos; Trietsch, Sebastian; Stuut, Christaan; Nieskens, Tom; Peters, Janny; Ramp, Daniela; Russel, Frans; Jacobson, Björn; Roth, Adrian; Lu, Shuyan; Polli, Joseph (2021-04-04)
    Journal of Pharmaceutical Sciences
    Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Stabilizing enzymes within polymersomes by coencapsulation of trehalose 

    Saxer, Sina; Pieles, Uwe; Dinu, Maria Valentina; Dinu, Ionel Adrian; Meier, Wolfgang; Bruns, Nico; Bruns, Nico (2020-06-22)
    Enzymes are essential biocatalysts and very attractive as therapeutics. However, their functionality is strictly related to their stability, which is significantly affected by the environmental changes occurring during ...
    01 - Zeitschriftenartikel, Journalartikel oder Magazin
  • Scale-Up of the agitator speed based on computational fluid dynamics 

    Zogg, Andreas; Maier, Christian David (2021)
    Siegfried in Zofingen is currently working on a hydrogenation reaction. To mimic the production condition for the production, the reaction is carried out on a scale-down reactor laboratory scale (approx. 1 liter). One ...
    05 - Forschungs- oder Arbeitsbericht

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