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dc.contributor.authorPaque, Pune
dc.contributor.authorSchmidlin, Patrick
dc.contributor.authorWiedemeier, Daniel
dc.contributor.authorWegehaupt, Florian
dc.contributor.authorBurrer, Phoebe
dc.contributor.authorKörner, Philipp
dc.contributor.authorDeari, Shengjile
dc.contributor.authorSciotti, Michel
dc.contributor.authorAttin, Thomas
dc.date.accessioned2022-03-14T06:50:51Z
dc.date.available2022-03-14T06:50:51Z
dc.date.issued2021-01-19
dc.identifier.doi10.3390/ijerph18020835
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/33344
dc.identifier.urihttp://dx.doi.org/10.26041/fhnw-4127
dc.description.abstractEnzymes in toothpastes can support host immune responses, and thus maintain oral health. This study aimed to investigate gingival health and the plaque-reducing effects of enzyme-containing toothpastes. A laboratory study tested the antimicrobial potential of different enzyme-containing toothpaste formulations. Two promising formulations (enzyme-containing toothpastes with glucose oxidase and D-glucose with (C+) and without Citrox (C−) Citrox) were investigated in a clinical crossover trial (two slurries: sodium lauryl sulfate-containing (SLS), a toothpaste without SLS (reference), and water). Subjects (n = 20) abstained from toothbrushing for four days and rinsed with a toothpaste slurry. Bleeding on probing (BOP) and plaque indices (PI) were measured. A mixed linear model was used to statistically compare the slurries with respect to BOP and PI change. The in vitro bacterial growth-inhibiting evaluation showed the best results for SLS, followed by C+ and C−. The change in BOP and PI exhibited statistically significant differences to water rinsing (BOP; PI changes in % points (difference of the baseline and post-rinse values: water = 8.8%; 90.0%; C+ = −1.4%; 80.4%; SLS = 1.5%; 72.1%; reference = 0.8%; 77.5%; C− = −1.8%; 75.1%). All slurries exhibited anti-gingivitis and anti-plaque effects, resulting in a prophylactic benefit for limited-access regions during brushing.en_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en_US
dc.accessRightsAnonymous*
dc.subjectGingivaen_US
dc.subjectToothbrushingen_US
dc.subjectDentifriceen_US
dc.subjectProphylaxisen_US
dc.subjectPreventionen_US
dc.subjectBacteriaen_US
dc.subjectGingivitisen_US
dc.subjectLow responderen_US
dc.subjectHigh responderen_US
dc.titleToothpastes with enzymes support gum health and reduce plaque formationen_US
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin*
dc.volume18en_US
dc.issue835en_US
dc.spatialBaselen_US
fhnw.publicationStatePublisheden_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.InventedHereYesen_US
fhnw.pagination1-14en_US
fhnw.IsStudentsWorknoen_US


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