Novel microcalorimetric assay for antibacterial activity of implant coatings. The cases of silver‐doped hydroxyapatite and calcium hydroxide
Vorschaubild nicht verfügbar
Autor:innen
Braissant, Olivier
Chavanne, Philippe
Stevanovic, Sabrina
Straumann, Lukas
Wirz, Dieter
Gruner, Philipp
Bachmann, Alexander
Autor:in (Körperschaft)
Publikationsdatum
08/2015
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
103
Ausgabe / Nummer
6
Seiten / Dauer
1161 - 1167
Patentnummer
Verlag / Herausgebende Institution
Wiley
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Biomaterials with antimicrobial properties are now commonly used in different clinical specialties including orthopedics, endodontic, and traumatology. As a result, assessing the antimicrobial effect of coatings applied on implants is of critical importance. In this study, we demonstrate that isothermal microcalorimetry (IMC) can be used for monitoring bacterial growth and biofilm formation at the surface of such coatings and for determining their antimicrobial effects. The antibacterial effects of silver doped hydroxyapatite (HA) and calcium hydroxide coatings on Staphylococcus epidermidis were determined with a minimal workload. Using the Gompertz growth model we determined biofilm growth rates close to those values reported in the literature. Furthermore, we were able to estimate the reduction in the bacterial inocula originally applied at the surface of the coatings. Therefore, in addition to monitoring the antimicrobial effect of silver doped HA and calcium hydroxide coatings, we also demonstrate that IMC might be a valuable tool for assessing such antimicrobial properties of implant coatings at a minimal workload.
Schlagwörter
Antibacterial implant coatings, Calcium hydroxide, Hydroxyapatite, Isothermal microcalorimetry, Staphylococcus
Fachgebiet (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1552-4973
1552-4981
1552-4981
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Closed
Lizenz
Zitation
BRAISSANT, Olivier, Philippe CHAVANNE, Michael DE WILD, Uwe PIELES, Sabrina STEVANOVIC, Ralf SCHUMACHER, Lukas STRAUMANN, Dieter WIRZ, Philipp GRUNER, Alexander BACHMANN und Gernot BONKAT, 2015. Novel microcalorimetric assay for antibacterial activity of implant coatings. The cases of silver‐doped hydroxyapatite and calcium hydroxide. Journal of Biomedical Materials Research Part B: Applied Biomaterials. August 2015. Bd. 103, Nr. 6, S. 1161 – 1167. DOI 10.1002/jbm.b.33294. Verfügbar unter: https://irf.fhnw.ch/handle/11654/45841