Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
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Autor:innen
Luppi, Andrea I.
Golkowski, Daniel
Ranft, Andreas
Ilg, Rüdiger
Menon, David K.
Stamatakis, Emmanuel A.
Autor:in (Körperschaft)
Publikationsdatum
2021
Typ der Arbeit
Studiengang
Sammlung
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Human Brain Mapping
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
42
Ausgabe / Nummer
9
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Wiley
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting‐state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small‐world character. Crucially, these effects are reversed upon recovery, demonstrating their association with consciousness. Higher doses of sevoflurane (3% vol and burst‐suppression) also compromise the temporal balance of integration and segregation in the human brain. Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub‐state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery.
Schlagwörter
Anaesthesia, Complexity, Consciousness, Dynamic functional connectivity, Integration - segregation, Sevoflurane, Small-world network
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1065-9471
1097-0193
1097-0193
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Gold
Lizenz
Zitation
LUPPI, Andrea I., Daniel GOLKOWSKI, Andreas RANFT, Rüdiger ILG, Denis JORDAN, David K. MENON und Emmanuel A. STAMATAKIS, 2021. Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane. Human Brain Mapping. 2021. Bd. 42, Nr. 9. DOI 10.1002/hbm.25405. Verfügbar unter: https://doi.org/10.26041/fhnw-9498