Bufadienolides from Helleborus foetidus and their cytotoxic properties on MCF-7 breast cancer cells

Twelve bufadienolides and six 19-norbufadienolides were isolated from the aerial parts of Helleborus foetidus. They consist of aglycons and glucosides and include nine previously undescribed compounds and a compound reported for the first time as a genuine natural product. Their structures were established by extensive spectroscopic analysis and the structure and absolute configuration of two previously unreported 3,4-epoxy derivatives were confirmed by single crystal X-ray diffraction analysis. The compounds were tested for their cytotoxicity on MCF-7 human breast cancer cells. They show differential cytotoxic activity with IC50 values in the range of 2.4 nM - >10 μM. The potency of the activity strongly correlates with the presence of a C-19 aldehyde group. The data complement the scientific basis underpinning the use of H. foetidus in anthroposophic medicine for the integrative treatment of cancer.

Schlagwörter

Helleborus foetidus, Ranunculaceae, Bufadienolides, Cytotoxicity, MCF-7 cells

Fachgebiet (DDC)

500 - Naturwissenschaften und Mathematik

Projekt

Veranstaltung

Startdatum der Ausstellung

Enddatum der Ausstellung

Startdatum der Konferenz

Enddatum der Konferenz

Datum der letzten Prüfung

ISBN

ISSN

0031-9422
1873-3700

Sprache

Englisch

Während FHNW Zugehörigkeit erstellt

Ja

Zukunftsfelder FHNW

Publikationsstatus

Veröffentlicht

Begutachtung

Peer-Review der ganzen Publikation

Open Access-Status

Hybrid

Lizenz

Zitation

Potterat, O., Kaufmann, M., Tschopp, C., Caj, M., Reinhardt, J. K., Prescimone, A., Shah, D., Baumgartner, S., Sciotti, M., & Suter-Dick, L. (2025). Bufadienolides from Helleborus foetidus and their cytotoxic properties on MCF-7 breast cancer cells. Phytochemistry, 230, 114329. https://doi.org/10.1016/j.phytochem.2024.114329

Komplettanzeige