Acoustic stimulation during sleep predicts long-lasting increases in memory performance and beneficial amyloid response in older adults

Sleep and neurodegeneration are assumed to be locked in a bi-directional vicious cycle. Improving sleep could break this cycle and help to prevent neurodegeneration. We tested multi-night phase-locked acoustic stimulation (PLAS) during slow wave sleep (SWS) as a non-invasive method to improve SWS, memory performance and plasma amyloid levels.32 healthy older adults (agemean: 68.9) completed a between-subject sham-controlled three-night intervention, preceded by a sham-PLAS baseline night.PLAS induced increases in sleep-associated spectral-power bands as well as a 24% increase in slow wave-coupled spindles, known to support memory consolidation. There was no significant group-difference in memory performance or amyloid-beta between the intervention and control group. However, the magnitude of PLAS-induced physiological responses were associated with memory performance up to 3 months post intervention and beneficial changes in plasma amyloid. Results were exclusive to the intervention group.Multi-night PLAS is associated with long-lasting benefits in memory and metabolite clearance in older adults, rendering PLAS a promising tool to build upon and develop long-term protocols for the prevention of cognitive decline.

Schlagwörter

Fachgebiet (DDC)

150 - Psychologie

Projekt

Veranstaltung

Startdatum der Ausstellung

Enddatum der Ausstellung

Startdatum der Konferenz

Enddatum der Konferenz

Datum der letzten Prüfung

9/23/2025

ISBN

1468-2834

ISSN

1468-2834
0002-0729

Sprache

Deutsch

Während FHNW Zugehörigkeit erstellt

Ja

Zukunftsfelder FHNW

Future Health

Publikationsstatus

Veröffentlicht

Begutachtung

Peer-Review der ganzen Publikation

Open Access-Status

Hybrid

Lizenz

Zitation

Wunderlin, M., Zeller, C. J., Senti, S. R., Fehér, K. D., Suppiger, D., Wyss, P., Koenig, T., Teunissen, C. E., Nissen, C., Klöppel, S., & Züst, M. A. (2023). Acoustic stimulation during sleep predicts long-lasting increases in memory performance and beneficial amyloid response in older adults. Age and Ageing, 52(12). https://doi.org/10.1093/ageing/afad228

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