Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine

dc.accessRightsAnonymous*
dc.contributor.authorDelaval, Mathilde N.
dc.contributor.authorJonsdottir, Hulda R.
dc.contributor.authorLeni, Zaira
dc.contributor.authorKeller, Alejandro
dc.contributor.authorBrem, Benjamin T.
dc.contributor.authorSiegerist, Frithjof
dc.contributor.authorSchönenberger, David
dc.contributor.authorDurdina, Lukas
dc.contributor.authorElser, Miriam
dc.contributor.authorSalathe, Matthias
dc.contributor.authorBaumlin, Nathalie
dc.contributor.authorLobo, Prem
dc.contributor.authorBurtscher, Heinz
dc.contributor.authorLiati, Anthi
dc.contributor.authorGeiser, Marianne
dc.date.accessioned2023-02-03T09:51:05Z
dc.date.available2023-02-03T09:51:05Z
dc.date.issued2022-08-15
dc.description.abstractHealth effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto reconstituted human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine was evaluated under realistic engine conditions by sampling and exposing HBE derived from donors of normal and compromised health status to exhaust for 1 h followed by biomarker analysis 24 h post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 109 particles cm−2 or 337.1 ng cm−2. Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings.en_US
dc.identifier.doi10.1016/j.envpol.2022.119521
dc.identifier.issn1873-6424
dc.identifier.issn0269-7491
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/34527.1
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEnvironmental Pollutionen_US
dc.subjectAerosolen_US
dc.subjectAircraft engine exhausten_US
dc.subjectBronchial epithelial cell cultureen_US
dc.subjectCellular responseen_US
dc.subjectNon-volatile particulate matteren_US
dc.subject.ddc660 - Technische Chemieen_US
dc.titleResponses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engineen_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift*
dc.volume307en_US
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.openAccessCategoryHybrid
fhnw.publicationStatePublisheden_US
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