Auflistung nach Autor:in "Gruner, Philipp"

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  • Vorschaubild nicht verfügbar
    Publikation
    A new model of implant-related osteomyelitis in the metaphysis of rat tibiae
    (BioMed Central, 08.04.2016) Harrasser, Norbert; Gorkotte, Johannes; Obermeier, Andreas; Feihl, Susanne; Straub, Melanie; Slotta-Huspenina, Julia; von Eisenhart-Rothe, Ruediger; Moser, Walter; Gruner, Philipp; de Wild, Michael; Gollwitzer, Hans; Burgkart, Rainer [in: BMC Musculoskeletal Disorders]
    Animal models serve as an important tool to understand peri-implant infection. Most of the models use high bacterial loads (>104 colony forming units, CFU) to provide high infection rates. Therefore these animals evolve rather similarly, making comparison between groups and statistical analysis possible. On the other hand, to mimic clinical constellation of surgery-related infections the use of low amounts of bacteria would be more advantageous.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    An inorganic antimicrobial surface modification for orthopaedic implants
    (2017) Gruner, Philipp; Moser, Walter; Wittwer, Marc; de Wild, Michael
    06 - Präsentation
  • Vorschaubild nicht verfügbar
    Publikation
    Improvement of mechanical properties of 3D printed hydroxyapatite scaffolds by culture of osteoblast-like cells under perfusion flow
    (2015) Rimmer, Natalie; Burgio, Floriana; Rohner, Adrian; Chavanne, Philippe; Zimmermann, Simon; Gruner, Philipp; Schumacher, Ralf; de Wild, Michael; Papadimitropoulos, Adam; Martin, Yvan; Hugot Beaufils, Marina; Pieles, Uwe [in: European Cells and Materials Conference Meeting Abstracts]
    04B - Beitrag Konferenzschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Novel microcalorimetric assay for antibacterial activity of implant coatings. The cases of silver‐doped hydroxyapatite and calcium hydroxide
    (Wiley, 08/2015) Braissant, Olivier; Chavanne, Philippe; de Wild, Michael; Pieles, Uwe; Stevanovic, Sabrina; Schumacher, Ralf; Straumann, Lukas; Wirz, Dieter; Gruner, Philipp; Bachmann, Alexander; Bonkat, Gernot [in: Journal of Biomedical Materials Research Part B: Applied Biomaterials]
    Biomaterials with antimicrobial properties are now commonly used in different clinical specialties including orthopedics, endodontic, and traumatology. As a result, assessing the antimicrobial effect of coatings applied on implants is of critical importance. In this study, we demonstrate that isothermal microcalorimetry (IMC) can be used for monitoring bacterial growth and biofilm formation at the surface of such coatings and for determining their antimicrobial effects. The antibacterial effects of silver doped hydroxyapatite (HA) and calcium hydroxide coatings on Staphylococcus epidermidis were determined with a minimal workload. Using the Gompertz growth model we determined biofilm growth rates close to those values reported in the literature. Furthermore, we were able to estimate the reduction in the bacterial inocula originally applied at the surface of the coatings. Therefore, in addition to monitoring the antimicrobial effect of silver doped HA and calcium hydroxide coatings, we also demonstrate that IMC might be a valuable tool for assessing such antimicrobial properties of implant coatings at a minimal workload.
    01A - Beitrag in wissenschaftlicher Zeitschrift