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- Publikation3D human liver microtissues vs. 2D monolayer culture as an in vitro tool for compound testing(10/2018) Messner, Catherine; Prestigiacomo, Vincenzo; Mannino, Salvatore; Mauch, Linda; Suter-Dick, Laura06 - Präsentation
- Publikation3D manufacturing of metallic implants(05/2016) de Wild, MichaelThe design, manufacturing and testing of load-bearing implants made of titanium, titanium alloy and magnesium produced by selective laser melting (SLM) will be presented. Analytical, structural, mechanical, in-silico, in-vitro and in-vivo studies are indispensable to verify the performance of such novel biomaterials. In particular the results from 3D-printed shape memory implants will be discussed.06 - Präsentation
- Publikation3D printed microfluidic modules. Passive mixers and cells encapsulation in alginate(De Gruyter, 02.09.2022) Dalcanale, Federico; Caj, Michaela; Schuler, Felix; Ganeshanathan, Kireedan; Suter-Dick, Laura [in: Current Directions in Biomedical Engineering]Passive mixers and droplet generation microfluidic chip modules were designed and manufactured using a commercial SLA 3D-printer. The mixing modules were designed specifically for 3D-printing and evaluated using FEM modeling. The co-flow droplet generator was used for cancer cells encapsulation and drug potency evaluation.01A - Beitrag in wissenschaftlicher Zeitschrift
- Publikation3D Printing and Medical Applications - an Overview(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D Printing in Medicine: Revolution or Illusion?(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D Printing in Medicine: Revolution or Illusion?(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D Printing in Medicine: Yesterday – Today - Tomorrow(06/2016) Schumacher, Ralf06 - Präsentation
- Publikation06 - Präsentation
- Publikation3D Visualization of intraoperative stimulation test results for better target selection in DBS surgery (U-PP-04)(2016) Shah, Ashesh; Alonso, Fabiola; Pison, Daniela; Lemaire, Jean-Jaques; Wårdell, Karin; Coste, Jérôme; Schkommodau, Erik; Hemm-Ode, Simone06 - Präsentation
- Publikation3D-Druck in der Medizintechnik – Revolution, Evolution oder Illusion?(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D-Druck und neue Geschäftsmodelle in der Medizintechnik(2015) Schumacher, Ralf06 - Präsentation
- Publikation3D-Druck wird Chirurgen die Operationen erleichtern(Swiss Professional Media, 04/2015) Schumacher, Ralf [in: Technische Rundschau]01B - Beitrag in Magazin oder Zeitung
- Publikation3D-printed auxetic structures for bio-medical application(2018) Schuler, Felix; Renaud, Pascal; de Wild, Michael [in: Swiss Society for Biomaterials and Regenerative Medicine]04 - Beitrag Sammelband oder Konferenzschrift
- Publikation3D-printed LEGO®-inspired titanium scaffolds for patient-specific regenerative medicine(Elsevier, 2023) Lee, Seunghun S.; Du, Xiaoyu; Smit, Thijs; Bissacco, Elisa G.; Seiler, Daniel; de Wild, Michael; Ferguson, Stephen J. [in: Biomaterials Advances]Despite the recent advances in 3D-printing, it is often difficult to fabricate implants that optimally fit a defect size or shape. There are some approaches to resolve this issue, such as patient-specific implant/scaffold designs based on CT images of the patients, however, this process is labor-intensive and costly. Especially in developing countries, affordable treatment options are required, while still not excluding these patient groups from potential material and manufacturing advances. Here, a selective laser melting (SLM) 3D-printing strategy was used to fabricate a hierarchical, LEGO®-inspired Assemblable Titanium Scaffold (ATS) system, which can be manually assembled in any shape or size with ease. A surgeon can quickly create a scaffold that would fit to the defect right before the implantation during the surgery. Additionally, the direct inclusion of micro- and macroporous structures via 3D-printing, as well as a double acid-etched surface treatment (ST) in the ATS, ensure biocompatibility, sufficient nutrient flow, cell migration and enhanced osteogenesis. Three different structures were designed (non-porous:NP, semi-porous:SP, ultra-porous:UP), 3D-printed with the SLM technique and then surface treated for the ST groups. After analyzing characteristics of the ATS such as printing quality, surface roughness and interconnected porosity, mechanical testing and finite element analysis (FEA) demonstrated that individual and stacked ATS have sufficient mechanical properties to withstand loading in a physiological system. All ATS showed high cell viability, and the SP and UP groups demonstrated enhanced cell proliferation rates compared to the NP group. Furthermore, we also verified that cells were well-attached and spread on the porous structures and successful cell migration between the ATS units was seen in the case of assemblies. The UP and SP groups exhibited higher calcium deposition and RT-qPCR proved higher osteogenic gene expression compared to NP group. Finally, we demonstrate a number of possible medical applications that reveal the potential of the ATS through assembly. © 2023 The Authors01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA Biocatalytic Nanomaterial for the Label-Free Detection of Virus-Like Particles(Wiley, 2017) Sykora, Sabine; Correro, Maria Rita; Moridi, Negar; Belliot, Gaël; Pothier, Pierre; Dudal, Yves; Corvini, Philippe; Shahgaldian, Patrick [in: ChemBioChem]The design of nanomaterials that are capable of specific and sensitive biomolecular recognition is an on-going challenge in the chemical and biochemical sciences. A number of sophisticated artificial systems have been designed to specifically recognize a variety of targets. However, methods based on natural biomolecular detection systems using antibodies are often superior. Besides greater affinity and selectivity, antibodies can be easily coupled to enzymatic systems that act as signal amplifiers, thus permitting impressively low detection limits. The possibility to translate this concept to artificial recognition systems remains limited due to design incompatibilities. Here we describe the synthesis of a synthetic nanomaterial capable of specific biomolecular detection by using an internal biocatalytic colorimetric detection and amplification system. The design of this nanomaterial relies on the ability to accurately grow hybrid protein-organosilica layers at the surface of silica nanoparticles. The method allows for label-free detection and quantification of targets at picomolar concentrations.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA cyclodextrin-based polymer (CDP) for sensing diclofenac in water(Elsevier, 15.12.2015) Xiao, Pu; Weibel, Nicolas; Dudal, Yves; Corvini, Philippe; Shahgaldian, Patrick [in: Journal of Hazardous Materials]01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA diffusing wave spectroscopy study of pharmaceutical emulsions for physical stability assessment(Elsevier, 2017) Niederquell, Andreas; Machado, Alexandra H.E.; Kuentz, Martin [in: International Journal of Pharmaceutics]Emulsions are broadly used in pharmaceutics either as intermediate products or as final dosage forms. Such disperse systems are only kinetically stabilized and therefore early detection of physical instability is highly desirable. This work employed diffusing wave spectroscopy (DWS) to study a series of model emulsions that were categorized, based on their composition, as either “simple” or “complex”. DWS data were compared with results of droplet size imaging, apparent viscosity obtained by microfluidics, and near-infrared (NIR) analytical centrifugation. A mathematical model of the droplet mean square displacement (MSD) was modified by us regarding improved fitting of experimental data. Although the emulsions showed different types of instability like creaming and sedimentation, a good rank correlation was found between the DWS parameters and results from the comparative stability methods. Our findings indicate that DWS provides a highly attractive method for stability analysis of pharmaceutical emulsions because it requires only low sample volumes, is rapid and non-invasive. The proposed data modeling provides the means for a better understanding of emulsion microstructure that in turn will help designing quality into pharmaceutical dispersions.01A - Beitrag in wissenschaftlicher Zeitschrift