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Design of miniaturized electro spray instrument for gene and drug therapeutic treatment of IPF
(De Gruyter, 2013) Fiave, Prosper Agbesi; Boehringer, Stephan; Gazdhar, Amiq; Geiser, Thomas; Hradetzky, David
Electric field accelerated plasmid droplets to permeate tissues has been demonstrated on cell culture and ex-vivo lung tissue of rats using enhanced green fluorescence protein reporter gene for transfection. This opens a window of opportunity to design an electrospray instrument usable within the working channel of bronchoscope to noninvasively treat idiopathic pulmonary fibrosis (IPF). We elaborate a concept and realized a device usable in the working channel of a flexible bronchoscope taking into account restrictions within typical bronchoscopy procedure.
01A - Beitrag in wissenschaftlicher Zeitschrift