Hochschule für Architektur, Bau und Geomatik FHNW
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Publikation Criticality creates a functional platform for network transitions between internal and external processing modes in the human brain(Frontiers Research Foundation, 2021) Kim, Minkyung; Kim, Hyoungkyu; Huang, Zirui; Mashour, George A.; Jordan, Denis; Ilg, Rüdiger; Lee, UnCheolContinuous switching between internal and external modes in the brain appears important for generating models of the self and the world. However, how the brain transitions between these two modes remains unknown. We propose that a large synchronization fluctuation of brain networks, emerging only near criticality (i.e., a balanced state between order and disorder), spontaneously creates temporal windows with distinct preferences for integrating the network’s internal information or for processing external stimuli. Using a computational model, electroencephalography (EEG) analysis, and functional magnetic resonance imaging (fMRI) analysis during alterations of consciousness in humans, we report that synchronized and incoherent networks, respectively, bias toward internal and external information with specific network configurations. In the brain network model and EEG-based network, the network preferences are the most prominent at criticality and in conscious states associated with the bandwidth 4−12 Hz, with alternating functional network configurations. However, these network configurations are selectively disrupted in different states of consciousness such as general anesthesia, psychedelic states, minimally conscious states, and unresponsive wakefulness syndrome. The network preference for internal information integration is only significant in conscious states and psychedelic states, but not in other unconscious states, suggesting the importance of internal information integration in maintaining consciousness. The fMRI co-activation pattern analysis shows that functional networks that are sensitive to external stimuli–such as default mode, dorsal attentional, and frontoparietal networks–are activated in incoherent states, while insensitive networks, such as global activation and deactivation networks, are dominated in highly synchronized states. We suggest that criticality produces a functional platform for the brain’s capability for continuous switching between two modes, which is crucial for the emergence of consciousness.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury(Frontiers Research Foundation, 2021) Golkowski, Daniel; Willnecker, Rebecca; Rösler, Jennifer; Ranft, Andreas; Schneider, Gerhard; Jordan, Denis; Ilg, RüdigerThe neurophysiology of the subjective sensation of being conscious is elusive; therefore, it remains controversial how consciousness can be recognized in patients who are not responsive but seemingly awake. During general anesthesia, a model for the transition between consciousness and unconsciousness, specific covariance matrices between the activity of brain regions that we call patterns of global brain communication reliably disappear when people lose consciousness. This functional magnetic imaging study investigates how patterns of global brain communication relate to consciousness and unconsciousness in a heterogeneous sample during general anesthesia and after brain injury. First, we describe specific patterns of global brain communication during wakefulness that disappear during propofol and sevoflurane general anesthesia. Second, we search for these patterns in a cohort of unresponsive wakeful patients and unmatched healthy controls in order to evaluate their potential use in clinical practice. We found that patterns of global brain communication characterized by high covariance in sensory and motor areas or low overall covariance and their dynamic change were strictly associated with intact consciousness in this cohort. In addition, we show that the occurrence of these two patterns is significantly related to activity within the frontoparietal network of the brain, a network known to play a crucial role in conscious perception. We propose that this approach potentially recognizes consciousness in the clinical routine setting.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Criticality creates a functional platform for network transitions between internal and external processing modes in the human brain(Frontiers Research Foundation, 2021) Kim, Minkyung; Kim, Hyoungkyu; Huang, Zirui; Mashour, George A.; Jordan, Denis; Ilg, Rüdiger; Lee, UnCheolContinuous switching between internal and external modes in the brain appears important for generating models of the self and the world. However, how the brain transitions between these two modes remains unknown. We propose that a large synchronization fluctuation of brain networks, emerging only near criticality (i.e., a balanced state between order and disorder), spontaneously creates temporal windows with distinct preferences for integrating the network’s internal information or for processing external stimuli. Using a computational model, electroencephalography (EEG) analysis, and functional magnetic resonance imaging (fMRI) analysis during alterations of consciousness in humans, we report that synchronized and incoherent networks, respectively, bias toward internal and external information with specific network configurations. In the brain network model and EEG-based network, the network preferences are the most prominent at criticality and in conscious states associated with the bandwidth 4−12 Hz, with alternating functional network configurations. However, these network configurations are selectively disrupted in different states of consciousness such as general anesthesia, psychedelic states, minimally conscious states, and unresponsive wakefulness syndrome. The network preference for internal information integration is only significant in conscious states and psychedelic states, but not in other unconscious states, suggesting the importance of internal information integration in maintaining consciousness. The fMRI co-activation pattern analysis shows that functional networks that are sensitive to external stimuli–such as default mode, dorsal attentional, and frontoparietal networks–are activated in incoherent states, while insensitive networks, such as global activation and deactivation networks, are dominated in highly synchronized states. We suggest that criticality produces a functional platform for the brain’s capability for continuous switching between two modes, which is crucial for the emergence of consciousness.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane(Wiley, 2021) Luppi, Andrea I.; Golkowski, Daniel; Ranft, Andreas; Ilg, Rüdiger; Jordan, Denis; Menon, David K.; Stamatakis, Emmanuel A.The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting‐state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small‐world character. Crucially, these effects are reversed upon recovery, demonstrating their association with consciousness. Higher doses of sevoflurane (3% vol and burst‐suppression) also compromise the temporal balance of integration and segregation in the human brain. Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub‐state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Silage bale detection for the «Cultivable Area» update of the Cantonal Agricultural Office, Thurgau(Institut Geomatik, Hochschule für Architektur, Bau und Geomatik FHNW, 09/2022) Adrian F. Meyer; Jordan, DenisIn Switzerland direct subsidies are paid to farms for sustainable agricultural practice. The cultivable agricultural area layer (German: Landwirtschaftliche Nutzfläche, LN) serves as an annual basis for the calculation of these contributions at the Swiss cantonal agricultural offices. Material deposits like silage bale stacks are usually excluded from the LN. Therefore, the canton of Thurgau could profit from a spatial vector layer indicating locations and area consumption extent of silage bale stacks intersecting with the LN perimeter.05 - Forschungs- oder ArbeitsberichtPublikation Traffic impact of flexibly rented, private parking spaces(11.04.2024) Erath, Alexander; Meyer, Adrian; Venuleo, Sara; Jordan, Denis; Büttner, Benjamin; Wulfhorst, Gebhard04B - Beitrag KonferenzschriftPublikation Verkehrliche Wirkung der flexiblen Vermietung privater Parkfelder(Fachhochschule Nordwestschweiz FHNW, 27.11.2023) Erath, Alexander; Meyer, Adrian; Venuleo, Sara; Jordan, Denis05 - Forschungs- oder Arbeitsbericht