The contribution deals with ongoing research projects and methods being employed at the Academy of Art and Design’s Critical Media Lab and puts them into the context of current Media-Lab discussions such as the recently launched initiative “What’s a Media Lab” by Darren Wershler, Jussi Parikka and Lori Emerson, or the recently published book “New Laboratories” (De Gruyter 2016) by Charlotte Klonk of the BWG Cluster of Excellence in Berlin. These discourses at the interface of scholarly, scientific-technical and, above all, artistic research, focus, on the one hand, on situated practices and methods of experimentation and, on the other, address the hybridization and problematization of disciplinary and institutional knowledge and production spaces.