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Publikation Continuous in situ lactic acid extraction from sweet whey fermentation broth using a tubular membrane contactor(2022) Demmelmayer, Paul; Pérez, Alan; Riedl, Wolfgang; Kienberger, MarleneBackground Whey, as the major dairy by-product, has become a severe problem for the dairy industry because its demand has decreased, while its production has increased in the past years. Since the high demand for dairy products tends to further increase, suitable routes for whey valorization are required. Whey contains valuables like lactate, but due its composition matrix, processing is challenging. The high sugar content in whey makes it a potential feedstock to produce lactic acid (LA) via microbial fermentation. Still, the known drawbacks of biotechnological LA production, such as growth inhibition by the product, the use of neutralizers, low productivity, and high overall costs of the process must be overcome. In situ LA recovering using a suitable separation technology is a potential strategy to overcome the mentioned drawbacks. In this work, the in situ LA extraction from a whey fermentation broth was evaluated. Sweet whey was used as feedstock for lactic acid production via microbial fermentation, while LA was recovered by reactive liquid-liquid extraction using a tubular membrane contactor. Method The feed material used in this work is a fermentation broth from sweet whey, which was filtered prior to extraction experiments using microfiltration. In a first series of experiments, two-phase extraction experiments were conducted in temperature controlled separation funnels, to investigate different solvent phase combinations for the lactic acid extraction. Special attention was paid to replace commonly applied fossil-based solvents with green alternatives, such as deep eutectic solvents (DES). After extraction, the extract was treated in a back-extraction step to recover LA from the solvent phase. Here, an anti-solvent, e.g. heptane or p-cymene, was used to transfer LA to the receiving phase, which was water. Afterwards the performance of reactive liquid-liquid extraction of LA using a PTFE membrane contactor was evaluated by using two potential solvent phases, namely tri-n-octyl amine (TOA) with n-decanol and a DES formed from thymol and menthol. From the experimental results the overall mass transfer coefficient was calculated based on a rigorous mass transfer model to predict the LA concentration in both phases. Finally, performance of the in situ LA recovery from sweet whey by using membrane contactor was investigated from both, experimentally and theoretically points of view. Results & Conclusion In the two-phase extraction experiments, the reactive extractants Aliquat336, TOA, trioctylphosphinoxid (TOPO), and the mixture Aliquat336/TOA were found to be most efficient with the diluents 1-decanol, limonene, and a deep eutectic solvent consisting of thymol and menthol. Especially, the DES and limonene are promising as they can be produced from renewable resources. With respect to back-extraction, heptane and p-cymene showed the highest efficiencies for transferring lactic acid into the receiving phase water. In the next step, the selected solvents were used to perform LA recovery in the tubular membrane contactor from a model aqueous solution of LA and a fermentation broth of sweet whey. The proposed technology for valorizing dairy waste through LA biotechnological production shows the feasibility to scaling it up.06 - PräsentationPublikation A mobile collaboration and decision support system for the medical emergency departement(SciTePress, 2012) Brodbeck, Dominique; Degen, Markus; Reiss, Maximilian; Conchon, Emmanuel; Correia, Carlos; Fred, Ana; Gamboa, HugoA hospital emergency department is a complex work environment, where the availability of the right information at the right time is crucial for efficient and safe operation. The current technology in use for communication and information management is mostly based on telephones and stationary personal computers. Modern smartphones with their computational power, voice, image, and video capabilities have the potential to play a significant role in improving the flow of information in the emergency department. We developed a system that explicitly supports the work flows of an emergency department. In addition to mobile access to patient data and notifications about the availability of diagnostic findings, it provides the possibility to supply media captured on-site to the patient record, and directly supports the consultation process.04B - Beitrag KonferenzschriftPublikation Energy-related chemical research at the universities of applied sciences(Swiss Chemical Society, 2013) Riedl, Wolfgang; Fischer, Fabian; Marti, Roger; Brühwiler, DominikAn overview of current activities in the field of energy-related chemical research at the Swiss Universities of Applied Sciences is presented.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Sustainable Chemistry at the Universities of Applied Sciences(Swiss Chemical Society, 2012) Sanglard, Pauline; Rogano, Frank; Naef, Olivier; Riedl, Wolfgang; Crelier, Simon; Fischer, Fabian; Morganti, Franziska; Hinderling, ChristianAn overview of activities in the field of sustainable or 'green' chemistry at the Universities of Applied Sciences in Switzerland is presented.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Reinigungseffektivität und Kavitationsrauschpegel bei Ultraschall-unterstützter wässriger Reinigung von Medizinprodukten(2012) Jung, Christiane; Budesa, Boris; Fässler, Fabian; Uehlinger, Robert; Müller, Thomas; Schaffner, Patrik; Bläsi, Simon; de Wild, Michael04B - Beitrag KonferenzschriftPublikation Prozessoptimierung von 4 Stufen zur Herstellung eines Pharma-Zwischenprodukts(Hochschule für Life Sciences FHNW, 2024) Güner, Merve; Zogg, Andreas11 - Studentische ArbeitPublikation Development of a tool for the automated visualization of batch recipes(Hochschule für Life Sciences FHNW, 2024) Gentner, Jannick; Zogg, Andreas; Bachem AG11 - Studentische ArbeitPublikation Modified oligonucleotides(World Intellectual Property Organization, 08.01.1998) De Mesmaeker, Alain; Wendeborn, Sebastian; Lebreton, JaquesIt is one object of the present invention to provide an oligonucleotide of formula (1): 5'-(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside, wherein the oligonucleotide comprises at least one modified nucleotide dimer comprising two nucleoside analogs connected via an amide-bond that has a certain configuration; the synthesis of these compounds and their use in pharmaceutical preparations.12 - PatentPublikation Kontinuierliche Ethoxylierung(25.04.2024) Zogg, Andreas; Zahnd, This; Brönnimann, BenediktModellbasiertes Sicherheitskonzept für die Entwicklung einer kontinuierlichen Ethoxylierung. Modellvalidierung mittels kontinuierlichem Kalorimeter innerhalb einer Glove-Box.06 - PräsentationPublikation An integrative model for phytochrome B mediated photomorphogenesis. From protein dynamics to physiology(Public Library of Science, 19.05.2010) Rausenberger, Julia; Hussong, Andrea; Kircher, Stefan; Kirchenbauer, Daniel; Timmer, Jens; Nagy, Ferenc; Schäfer, Eberhard; Fleck, Christian; Harmon, FrankPlants have evolved various sophisticated mechanisms to respond and adapt to changes of abiotic factors in their natural environment. Light is one of the most important abiotic environmental factors and it regulates plant growth and development throughout their entire life cycle. To monitor the intensity and spectral composition of the ambient light environment, plants have evolved multiple photoreceptors, including the red/far-red light-sensing phytochromes.01A - Beitrag in wissenschaftlicher Zeitschrift