Zogg, Andreas

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Zogg
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Andreas
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Zogg, Andreas

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Typ: 01A - Beitrag in wissenschaftlicher Zeitschrift ×

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  • Vorschaubild
    Publikation
    Development of a novel measurement setup to study and predict electrostatic discharges in agitated glass‐lined vessels
    (Wiley, 12.02.2024) Brönnimann, Benedikt; Egli‐Tedesco, Daniel; Schwenzfeuer, Klaus; Zogg, Andreas [in: Helvetica Chimica Acta]
    Two glass lined reactors in a launch platform facility operated by Syngenta have been damaged during the crystallization of an organic compound due to electrostatic discharges. The goal of this work was to design and commission a novel setup to measure charges and currents generated by this slurry in a laboratory‐scale reactor. An improved and more sophisticated setup was then proposed for possible implementation in Syngenta's own laboratories. With this novel setup, the electrostatic charging of stirred suspensions involving nonconductive solvents could be accurately measured in the context of a case study that involved the suspension that led to liner damages in the production facilities of Syngenta.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild
    Publikation
    Modeling-based approach towards quality by design for a telescoped process
    (Schweizerische Chemische Gesellschaft, 2024) Zahnd, This; Kandziora, Maja; Levis, Michael K.; Zogg, Andreas [in: Chimia]
    A telescoped, two-step synthesis was investigated by applying Quality by Design principles. A kinetic model consisting of 12 individual reactions was successfully established to describe the synthesis and side reactions. The resulting model predicts the effects of changes in process parameters on total yield and quality. Contour plots were created by varying process parameters and displaying the model predicted process response. The areas in which the process response fulfils predetermined quality requirements are called design spaces. New ranges for process parameters were explored within these design spaces. New conditions were found that increased the robustness of the process and allowed for a considerable reduction of the used amounts of a reagent. Further optimizations, based on the newly generated knowledge, are expected. Improvements can either be direct process improvements or enhancements to control strategies. The developed strategies can also be applied to other processes, enhancing upcoming and preexisting research and development efforts.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    New scale-up technologies for multipurpose pharmaceutical production plants. Use case of a heterogeneous hydrogenation process
    (American Chemical Society, 06.07.2023) Furrer, Thierry; Levis, Michael; Berger, Bernhard; Kandziora, Maja; Zogg, Andreas [in: Organic Process Research & Development]
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild
    Publikation
    New scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants
    (Schweizerische Chemische Gesellschaft, 2021) Furrer, Thierry; Müller, Benedikt; Hasler, Christoph; Berger, Bernhard; Levis, Michael Karl; Zogg, Andreas [in: Chimia]
    The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Entwicklung eines neuartigen Rohrreaktorsystems für heterogen katalysierte Mehrphasenreaktionen
    (Wiley, 2017) Leonhardt, Tobias; Zogg, Andreas; Riedl, Wolfgang [in: Chemie Ingenieur Technik]
    Der einem inversen Festbettreaktor nachempfundene lasergesinterte Rohrreaktor stellt eine interessante Alternative zu anderen innovativen Reaktorkonzepten zur Prozessintensivierung dar. Im Rahmen dieser Arbeit wurde für diesen Reaktortyp eine geeignete Peripherie konzipiert. Das entwickelte Anlagenkonzept soll verschiedene chemische Reaktionen unter inhärent sicheren Bedingungen ermöglichen. Im Fokus stehen heterogen katalysierte Mehrphasenreaktionen, die einen mittleren bis hohen Enthalpiestrom abgeben. Am Beispiel einer oxidativen Zyklisierung wird die Funktionalität des Reaktorsystems beschrieben.
    01A - Beitrag in wissenschaftlicher Zeitschrift