Zdoryk, Oleksandr

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Zdoryk
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Oleksandr
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Oleksandr Zdoryk

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  • Vorschaubild
    Publikation
    Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds
    (Oles Honchar Dnipro National University, 2023) Krusir, Galyna; Pylypenko, Liudmyla; Sevastyanova, Elena; Mazurenko, Kseniia; Moshtakov, Serhii; Shunko, Hanna; Vitiuk, Antonina; Shpyrko, Tetyana; Zdoryk, Oleksandr [in: Journal of Chemistry and Technologies]
    Digestive enzymes and inhibitors of digestive enzymes are effective correctors of digestive processes in the body, the violation of which leads to various diseases (diabetes, hyperlipidemia, cardiovascular diseases, neoplasms and others). The present study identified the most promising plant objects characterized by the highest antilipolytic activity (ALA) in relation to pancreatic lipase. The experimental results indicate that the inhibitory activity (IA) of phenolic compounds of rapeseed is so much high and comparable to ALA "Orlistat", reaching 95.5 % of its activity. This determines the potential possibility of using the phenolic complex of rapeseed as an alternative to anti-lipolytic drugs of synthetic origin. The predominant component of the phenolic complex is low molecular weight phenolic compounds; polyphenolic compounds are almost equally represented by tannins – condensed and hydrolyzable. According to TLC data, the main components of low molecular weight phenols are glucopyranosylsinapate, sinapic acid and sinapin. Among the phenolic compounds of rapeseed seeds, sinapine and hydrolyzable tannins have the highest anti lipolytic activity against lipase. Significant ability to inhibit the action of pancreatic lipase is characterized by both low molecular weight and high molecular weight phenolic compounds of rapeseed.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild
    Publikation
    Analysis of the physical characteristics of an anhydrous vehicle for compounded pediatric oral liquids
    (MDPI, 2023) Banov, Daniel; Liu, Yi; Ip, Kendice; Shan, Ashley; Vu, Christine; Zdoryk, Oleksandr; Bassani, August S.; Carvalho, Maria [in: Pharmaceutics]
    The paucity of suitable drug formulations for pediatric patients generates a need for customized, compounded medications. This research study was set out to comprehensively analyze the physical properties of the new, proprietary anhydrous oral vehicle SuspendIt® Anhydrous, which was designed for compounding pediatric oral liquids. A wide range of tests was used, including sedimentation volume, viscosity, droplet size after dispersion in simulated gastric fluid, microscopic examination and content uniformity measurements to evaluate the properties of the anhydrous vehicle. The results showed that the vehicle exhibited consistent physical properties under varying conditions and maintained stability over time. This can be attributed to the unique blend of excipients in its formulation, which not only maintain its viscosity but also confer thixotropic behavior. The unique combination of viscous, thixotropic and self-emulsifying properties allows for rapid redispersibility, sedimentation stability, accurate dosing, potential drug solubility, dispersion and promotion of enhanced gastrointestinal distribution and absorption. Furthermore, the vehicle demonstrated long-term sedimentation stability and content uniformity for a list of 13 anhydrous suspensions. These results suggest that the anhydrous oral vehicle could serve as a versatile base for pediatric formulation, potentially filling an important gap in pediatric drug delivery. Future studies can further investigate its compatibility, stability and performance with other drugs and in different clinical scenarios.
    01A - Beitrag in wissenschaftlicher Zeitschrift