Hradetzky, David

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Hradetzky
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David
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Hradetzky, David

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2012 - 201932020 - 20221
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Anfangsdatum: 2010 × Thema: 600 - Technik, Medizin, angewandte Wissenschaften ×

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Gerade angezeigt 1 - 4 von 4
  • Vorschaubild nicht verfügbar
    Publikation
    Experience with a continuous education program for clinical. regulatory and quality affairs in Northwestern Switzerland
    (IEEE EMBC, 07/2022) Etter, Philippe; Lucano, Elena; Hradetzky, David [in: 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)]
    04B - Beitrag Konferenzschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Rapid prototyping method for 3D printed biomaterial constructs with vascular structures
    (IEEE, 2018) Gullo, Maurizio; Köser, Joachim; Ruckli, Oliver; Eigenmann, Andrej; Hradetzky, David [in: 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)]
    This paper presents a fabrication method for rapid prototyping of 3D biomaterial constructs with vascular structures. The method relies on poloxamer fugitive ink, which is over casted with a custom-made alginate based model extracellular matrix (ECM). The presented method is simple to implement and compatible with standard cell culture workflows used in biomedical research and pharmaceutical development. We present the material preparation, gelation properties and printing methods in detail. First experiments demonstrate the suitability of the ECM constructs for 3D tissue culture.
    04B - Beitrag Konferenzschrift
  • Vorschaubild nicht verfügbar
    Publikation
    Design of miniaturized electro spray instrument for gene and drug therapeutic treatment of IPF
    (De Gruyter, 2013) Fiave, Prosper Agbesi; Boehringer, Stephan; Gazdhar, Amiq; Geiser, Thomas; Hradetzky, David [in: Biomedical Engineering / Biomedizinische Technik]
    Electric field accelerated plasmid droplets to permeate tissues has been demonstrated on cell culture and ex-vivo lung tissue of rats using enhanced green fluorescence protein reporter gene for transfection. This opens a window of opportunity to design an electrospray instrument usable within the working channel of bronchoscope to noninvasively treat idiopathic pulmonary fibrosis (IPF). We elaborate a concept and realized a device usable in the working channel of a flexible bronchoscope taking into account restrictions within typical bronchoscopy procedure.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Vorschaubild nicht verfügbar
    Publikation
    An approach towards bronchoscopic-based gene therapy using electrical field accelerated plasmid droplets
    (IEEE, 2012) Hradetzky, David; Boehringer, Stephan; Geiser, Thomas; Gazdhar, Amiq [in: 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society]
    Idiopathic pulmonary fibrosis (IPF) is a devastating disease affecting the distal lung, due to failure of the alveolar epithelium to heal after micro-injuries, leading to inefficient gas exchange and resulting in death. Therapeutic options are very limited. A new therapeutic approach based on gene therapy restores the self-healing process within the lung in the experimental setup. A basic requirement of this therapy is the successful transduction of genes into the alveolar epithelium in the distal part of the lung, for which a new therapeutic instrument is required. In this paper we present the concept and first experimental results of a device which uses an electrical field to accelerate the charged droplets of plasmid suspension toward the tissue and which overcomes cell membrane with its impact energy. The aim is to develop a therapeutic device capable of being integrated into minimally invasive procedures such as bronchoscopy.
    04B - Beitrag Konferenzschrift