Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
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Author (Corporation)
Publication date
02.2016
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Trends in Biotechnology
Special issue
DOI of the original publication
Link
Series
Series number
Volume
34
Issue / Number
2
Pages / Duration
156-170
Patent number
Publisher / Publishing institution
Elsevier
Place of publication / Event location
Edition
Version
Programming language
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Practice partner / Client
Abstract
Improved model systems to predict drug efficacy, interactions, and drug induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation.
Keywords
Organ-on-a-chip, Nephrotoxicity, Drug screening, Microfluidics, High-throughput screening, Kidney
Subject (DDC)
Event
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ISBN
ISSN
0167-7799
1879-3096
1879-3096
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Future Health
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
License
Citation
Wilmer, M. J., Ng, C. P., Lanz, H. L., Vulto, P., Suter-Dick, L., & Masereeuw, R. (2016). Kidney-on-a-chip technology for drug-induced nephrotoxicity screening. Trends in Biotechnology, 34(2), 156–170. https://doi.org/10.1016/j.tibtech.2015.11.001