Kidney-on-a-chip technology for drug-induced nephrotoxicity screening
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Author (Corporation)
Publication date
02.2016
Type of student thesis
Course of study
Collections
Type
01A - Journal article
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Editor (Corporation)
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Parent work
Trends in Biotechnology
Special issue
DOI of the original publication
Link
Related research data
Series
Series number
Volume
34
Issue / Number
2
Pages / Duration
156-170
Patent number
Publisher / Publishing institution
Elsevier
Place of publication / Event location
Edition
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Abstract
Improved model systems to predict drug efficacy, interactions, and drug induced kidney injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a suitable in vitro system because it reproduces the 3D microenvironment. A kidney-on-a-chip can mimic the structural, mechanical, transport, absorptive, and physiological properties of the human kidney. In this review we address the application of state-of-the-art microfluidic culturing techniques, with a focus on culturing kidney proximal tubules, that are promising for the detection of biomarkers that predict drug interactions and DIKI. We also discuss high-throughput screening and the challenges for in vitro to in vivo extrapolation (IVIVE) that will need to be overcome for successful implementation.
Keywords
Organ-on-a-chip, Nephrotoxicity, Drug screening, Microfluidics, High-throughput screening, Kidney
Subject (DDC)
Event
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ISBN
ISSN
0167-7799
1879-3096
1879-3096
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Future Health
Publication status
Published
Review
peer-reviewed
Open access category
Closed
License
Citation
Wilmer, M. J., Ng, C. P., Lanz, H. L., Vulto, P., Suter-Dick, L., & Masereeuw, R. (2016). Kidney-on-a-chip technology for drug-induced nephrotoxicity screening. Trends in Biotechnology, 34(2), 156–170. https://doi.org/10.1016/j.tibtech.2015.11.001