Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy
Author (Corporation)
Publication date
08.08.2024
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Type
01A - Journal article
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Parent work
Clinical Oral Investigations
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Volume
28
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Springer
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Abstract
Objectives
Inadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS).
Materials and methods
LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins < 1 mm were defined as very close, from 1–5 mm as close, and > 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined.
Results
LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (p < 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%.
Conclusions
LIBS can reliably determine the boundary of bone-infiltrating tumors and might provide an orientation for determining a clear resection margin.
Clinical relevance
LIBS could facilitate intraoperative decision-making and avoid inadequate resection margins in bone-invasive oral cancer.
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ISBN
ISSN
1436-3771
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
Citation
WINNAND, Philipp, Mark OOMS, Marius HEITZER, Nils VOHL, Matthias LAMMERT, Frank HÖLZLE, Klaus Olaf BÖRNSEN und Ali MODABBER, 2024. Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy. Clinical Oral Investigations. 8 August 2024. Bd. 28. DOI 10.1007/s00784-024-05862-5. Verfügbar unter: https://doi.org/10.26041/fhnw-11886